中国药学杂志
中國藥學雜誌
중국약학잡지
CHINESE PHARMACEUTICAL JOURNAL
1998年
4期
214
,共1页
阎月%葛蒙梁%阎明%刘冬玲%段绍瑾
閻月%葛矇樑%閻明%劉鼕玲%段紹瑾
염월%갈몽량%염명%류동령%단소근
β-羧乙基锗倍半氧化物%维生素B1%肝线粒体%超氧化物歧化酶%谷胱甘肽过氧化物酶
β-羧乙基鍺倍半氧化物%維生素B1%肝線粒體%超氧化物歧化酶%穀胱甘肽過氧化物酶
β-최을기타배반양화물%유생소B1%간선립체%초양화물기화매%곡광감태과양화물매
β-carboxyethyl germanium sesquioxide%vitamin B1%liver mitochondria%superoxide dismutase%glutathion peroxidase
目的：探讨β-羧乙基锗倍半氧化物(Ge-132)与还原型谷胱甘肽(GSH)和维生素B1(VB1)联合应用在体内抗氧化的作用。方法：观察这些药物对乙醇诱发大鼠氧应激态作用下的抗氧化酶活性变化。结果：肝线粒体总超氧化物歧化酶和铜锌超氧化物歧化酶活性，乙醇组与正常对照组比较，其活性显著下降(P＜0.05)；乙醇+Ge-132+VB1+GSH组与乙醇组比较，肝线粒体酮锌超氧化物歧化酶(Cu，Zn-SOD)活性上升(P＜0.05)。结论：Ge-132与GSH和VB1联合应用对乙醇导致的自由基损伤有协同保护作用。
目的：探討β-羧乙基鍺倍半氧化物(Ge-132)與還原型穀胱甘肽(GSH)和維生素B1(VB1)聯閤應用在體內抗氧化的作用。方法：觀察這些藥物對乙醇誘髮大鼠氧應激態作用下的抗氧化酶活性變化。結果：肝線粒體總超氧化物歧化酶和銅鋅超氧化物歧化酶活性，乙醇組與正常對照組比較，其活性顯著下降(P＜0.05)；乙醇+Ge-132+VB1+GSH組與乙醇組比較，肝線粒體酮鋅超氧化物歧化酶(Cu，Zn-SOD)活性上升(P＜0.05)。結論：Ge-132與GSH和VB1聯閤應用對乙醇導緻的自由基損傷有協同保護作用。
목적：탐토β-최을기타배반양화물(Ge-132)여환원형곡광감태(GSH)화유생소B1(VB1)연합응용재체내항양화적작용。방법：관찰저사약물대을순유발대서양응격태작용하적항양화매활성변화。결과：간선립체총초양화물기화매화동자초양화물기화매활성，을순조여정상대조조비교，기활성현저하강(P＜0.05)；을순+Ge-132+VB1+GSH조여을순조비교，간선립체동자초양화물기화매(Cu，Zn-SOD)활성상승(P＜0.05)。결론：Ge-132여GSH화VB1연합응용대을순도치적자유기손상유협동보호작용。
OBJECTIVE: To examine the antioxidative effect of β-carboxyethyl germanium sesquioxide (Ge-132) combined with GSH and VB1 in vivo. METHODS: The effects of these drugs on rats under oxidative stress induced by ethanol were investigated by observing the activities of superoxide dismutase (SOD) in liver mitochondria and brain, and the activity of glutathion peroxidase (GSH-Px) in serum in the rats. RESULTS: The activity of CuZn-SOD in liver mitochondria decreased in the rats of ethanol group compared with that of the control group (P＜0.05), and increased in the ethanol +Ge-132 +VB1 +GSH group compared with ethanol group (P＜0.05). CONCLUSION: Ge-132 could protect from damage caused by free radical in ethanol feeding rats. There is a coordinated effect by combined administration of Ge-132 with GSH and VB1.
