CAJ | 학술논문

单核苷酸多态性(single nucleotide polymorphism,SNP)分型技术越来越成为法医学领域关注的热点.它在研究Y染色体或线粒体单倍型以及DNA表型的分析中具有重要应用价值.本文着重比较分析了SNP技术与片段长度多态性技术之间的优劣,同时就当前STR位点识别概率与所需选择的SNP位点数进行探讨.此外.本文还就各类SNP分型方法的优缺点及其法医学应用进行了论述.
단핵감산다태성(single nucleotide polymorphism,SNP)분형기술월래월성위법의학영역관주적열점.타재연구Y염색체혹선립체단배형이급DNA표형적분석중구유중요응용개치.본문착중비교분석료SNP기술여편단장도다태성기술지간적우렬,동시취당전STR위점식별개솔여소수선택적SNP위점수진행탐토.차외.본문환취각류SNP분형방법적우결점급기법의학응용진행료논술.
There is an increasing interest in single nucleotide polymorphism (SNP) typing in the forensic field.SNPs are very useful for deftning Y chromosome or mtDNA haplotypes and DNA phenotyping.We focus on comparative advantages of SNP typing over length variations and expected number of loci required to gain probabilities equal to sTR loci in use.This review also offers to the reader a state of the art of SNP genotyping technologies with the advantages and disadvantages of the different techniques and platforms for different forensic requirements.