CAJ | 학술논문

不同体重者下丘脑对葡萄糖耐量试验的反应
불동체중자하구뇌대포도당내량시험적반응
The central sensitivity of hypothalamus to oral glucose loading in subjects with different body weight

万方数据

中华糖尿病杂志中華糖尿病雜誌 중화당뇨병잡지
CHINESE JOURNAL OF DIABETES
2005年 5期 353-356 ,共4页

张铁梅%陈敏%罗森林%张颖%周天罡%张延%宫环%吴小萌%韩彩和%戴雪松%阎颖

장철매%진민%라삼림%장영%주천강%장연%궁배%오소맹%한채화%대설송%염영

下丘脑%磁共振成像,功能性%葡萄糖耐量试验下丘腦%磁共振成像,功能性%葡萄糖耐量試驗
하구뇌%자공진성상,공능성%포도당내량시험
Glucose tolerance test

目的应用功能核磁共振观察不同体重者下丘脑对口服葡萄糖耐量试验的反应,揭示不同体重者下丘脑中枢糖代谢调节的敏感性与代谢紊乱发生的关系. 方法分别采集10名正常体重者与10名肥胖者口服75克葡萄糖后的下丘脑功能磁共振图像数据以及腹部解剖结构图像数据; 同时测定受试者的空腹血糖、游离脂肪酸及相应激素水平.应用自行建立的灰度平均值方法进行图像分析处理; 同时进行受试者脑功能信号参数与血生化指标水平、相应激素水平及腹部脂肪含量的相关分析. 结果不同体重者口服葡萄糖后在下丘脑部位均出现一过性的抑制反应.但肥胖者此抑制反应出现的时间较正常体重者明显延迟; 抑制反应强度明显低于正常体重者;抑制反应恢复时间也明显迟于正常体重者.受试者的空腹血浆胰岛素及其痩素水平与其下丘脑抑制信号恢复到基线的时间有关联; 受试者的腹部脂肪含量与其下丘脑抑制信号恢复到基线的时间亦有关联.而受试者空腹血浆葡萄糖、游离脂肪酸水平与其下丘脑功能磁共振采集信号各项参数间没有关联. 结论不同体重者下丘脑对糖负荷的中枢反应有所不同,肥胖者下丘脑对糖刺激反应的敏感性有所降低.功能核磁共振是确定脑特定区域功能的一个有效手段.
목적응용공능핵자공진관찰불동체중자하구뇌대구복포도당내량시험적반응,게시불동체중자하구뇌중추당대사조절적민감성여대사문란발생적관계. 방법분별채집10명정상체중자여10명비반자구복75극포도당후적하구뇌공능자공진도상수거이급복부해부결구도상수거; 동시측정수시자적공복혈당、유리지방산급상응격소수평.응용자행건립적회도평균치방법진행도상분석처리; 동시진행수시자뇌공능신호삼수여혈생화지표수평、상응격소수평급복부지방함량적상관분석. 결과불동체중자구복포도당후재하구뇌부위균출현일과성적억제반응.단비반자차억제반응출현적시간교정상체중자명현연지; 억제반응강도명현저우정상체중자;억제반응회복시간야명현지우정상체중자.수시자적공복혈장이도소급기수소수평여기하구뇌억제신호회복도기선적시간유관련; 수시자적복부지방함량여기하구뇌억제신호회복도기선적시간역유관련.이수시자공복혈장포도당、유리지방산수평여기하구뇌공능자공진채집신호각항삼수간몰유관련. 결론불동체중자하구뇌대당부하적중추반응유소불동,비반자하구뇌대당자격반응적민감성유소강저.공능핵자공진시학정뇌특정구역공능적일개유효수단.
Objective To investigate central response of hypothalamus to 75 g oral glucose loading by functional magnetic resonance imaging(fMRI).Methods The signal of hypothalamus was monitored by fMRI for 50 minutes in 20 persons with two types of body weight(10 obese subjects and 10 normal body weight subjects) after 75 g oral glucose intake.The plasmas for leptin,insulin,free fatty acid and glucose determinations were also collected during the procedure.Results Both lean and obese subjects demonstrated an inhibition of the fMRI signal after glucose intake,but in obese subjects,the inhibition was attenuated and delayed compared with lean subjects(1.94±1.06 min vs 1.0 4±0.71 min,P<0.05).The time taken to recover to the base line after inhibition was also delayed compared with lean subjects(26.62±7.35 min vs 16.29±6.42 min,P<0.01)and correlated with the fasting plasma leptin,insulin concentrations and abdominal fat areas in both lean and obese subjects(r=0.718~0.509,P<0.05).Conclusion Hypothalamus response to glucose loading in lean and obese humans was different.The glucose-induced central sensitivity of hypothalamus was attenuated in obese subjects.