应用化学
應用化學
응용화학
CHINESE JOURNAL OF APPLIED CHEMISTRY
2010年
3期
370-372
,共3页
N-溴丁二酰亚胺%芳香胺%酚%溴化%新工艺
N-溴丁二酰亞胺%芳香胺%酚%溴化%新工藝
N-추정이선아알%방향알%분%추화%신공예
N-bromosuccinimide%aromatic amines%phenols%bromination%new process
研究了在室温下,N-溴丁二酰亚胺对芳香胺和酚的溴化工艺,在CHCl_3、EtOH或EtOH/CHCl_3溶剂中,用等摩尔的N-溴丁二酰亚胺可将某些芳香胺和酚(考察了5种反应底物)选择性地一溴化,产率92%～98%,N-溴丁二酰亚胺和反应底物摩尔比为2: 1;某些芳香胺和酚被专一地二溴化(考察了5种反应底物),产率90%～97%.反应无须催化剂,投料后室温搅拌,反应条件温和,产品只需过滤洗涤即可纯化,操作简便.
研究瞭在室溫下,N-溴丁二酰亞胺對芳香胺和酚的溴化工藝,在CHCl_3、EtOH或EtOH/CHCl_3溶劑中,用等摩爾的N-溴丁二酰亞胺可將某些芳香胺和酚(攷察瞭5種反應底物)選擇性地一溴化,產率92%～98%,N-溴丁二酰亞胺和反應底物摩爾比為2: 1;某些芳香胺和酚被專一地二溴化(攷察瞭5種反應底物),產率90%～97%.反應無鬚催化劑,投料後室溫攪拌,反應條件溫和,產品隻需過濾洗滌即可純化,操作簡便.
연구료재실온하,N-추정이선아알대방향알화분적추화공예,재CHCl_3、EtOH혹EtOH/CHCl_3용제중,용등마이적N-추정이선아알가장모사방향알화분(고찰료5충반응저물)선택성지일추화,산솔92%～98%,N-추정이선아알화반응저물마이비위2: 1;모사방향알화분피전일지이추화(고찰료5충반응저물),산솔90%～97%.반응무수최화제,투료후실온교반,반응조건온화,산품지수과려세조즉가순화,조작간편.
A new process for the Brominations of aromatic amines and phenols was reported. The reactions were carried out at room temperature with CHCl_3,EtOH or EtOH/CHCl_3 as solvent,selective monobromination of some aromatic amines and phenols occurred(five substrates were investigated) at a ratio of N-bromosuccinimide to substrate 1: 1,the yields were 92%～98%. Dibromination of some aromatic amines and phenols occur smoothly(five substrates were investigated),at a ratio of N-bromosuccinimide to substrate 2: 1,the yields were 90%～97%. As a green and environmentally benign method,the Brominations of aromatic amines and phenols could be achieved at room temperature without using catalysts. In addition,the final products could be collected after filtration and washing process.
