中国医药工业杂志
中國醫藥工業雜誌
중국의약공업잡지
CHINESE JOURNAL OF PHARMACEUTICALS
2001年
2期
53-55
,共3页
刘立云%李俊德%魏树辉
劉立雲%李俊德%魏樹輝
류립운%리준덕%위수휘
渗透性丙烯酸聚合物%控释微丸%盐酸地尔硫%释放度
滲透性丙烯痠聚閤物%控釋微汍%鹽痠地爾硫%釋放度
삼투성병희산취합물%공석미환%염산지이류%석방도
以渗透性丙烯酸聚合物(Eudragit RS)为包衣材料制备盐酸地尔硫FDA8控释微丸，体外释放度呈零级释放，释药速率常数为0.0635 h-1。释放度符合美国药典ⅩⅩⅢ版规定。微丸经3个月加速试验，质量稳定。
以滲透性丙烯痠聚閤物(Eudragit RS)為包衣材料製備鹽痠地爾硫FDA8控釋微汍，體外釋放度呈零級釋放，釋藥速率常數為0.0635 h-1。釋放度符閤美國藥典ⅩⅩⅢ版規定。微汍經3箇月加速試驗，質量穩定。
이삼투성병희산취합물(Eudragit RS)위포의재료제비염산지이류FDA8공석미환，체외석방도정령급석방，석약속솔상수위0.0635 h-1。석방도부합미국약전ⅩⅩⅢ판규정。미환경3개월가속시험，질량은정。
Controlled-release pellets of diltiazem hydrochloride were prepared by using Eudragit RS as coating material. The dissolution test in vitro showed that the drug release profile followed zero-order kinetic equation, and release rate constant was 0.0635 h-1. Good stability was indicated by accelerated test for 3 months.
