CAJ | 학술논문

目的：探讨无血管并发症的糖尿病(DM)和糖尿病肾病(DN)的降钙素基因相关肽(CGRP)、内皮素(ET)水平及其临床意义。方法：对照组43人，DM组45例，DN组40例，测定血浆CGRP、ET及血压。结果：DM组的CGRP比对照组、DN组显著增高(P＜0.01，P＜0.05)。DN组的ET比对照组、DM组显著增高(P＜0.01，P＜0.01)。三组的血压：DN组最高，DM组次之，对照组最低。对照组、DM组的CGRP与ET正相关，DN组的CGRP与ET无显著相关。结论：CGRP对血压的影响，在无血管并发症的DM大于DN。
목적：탐토무혈관병발증적당뇨병(DM)화당뇨병신병(DN)적강개소기인상관태(CGRP)、내피소(ET)수평급기림상의의。방법：대조조43인，DM조45례，DN조40례，측정혈장CGRP、ET급혈압。결과：DM조적CGRP비대조조、DN조현저증고(P＜0.01，P＜0.05)。DN조적ET비대조조、DM조현저증고(P＜0.01，P＜0.01)。삼조적혈압：DN조최고，DM조차지，대조조최저。대조조、DM조적CGRP여ET정상관，DN조적CGRP여ET무현저상관。결론：CGRP대혈압적영향，재무혈관병발증적DM대우DN。
Objective: To study level and clinical significance of plasma calcitonin gene related peptides (CGRP) and endothelin (ET) in patients with diabetes mellitus (DM) without blood vessel complication and in patients with diabetic nephropathy (DN).Methods: The plasma concentrations of CGRP, ET and blood pressure were measured in control group (43 subjects), DM group (45 cases) and DN group (40 eases). Results: CGRP of DM group showed significant elevation as compared with that of control group and DN group (P＜0.01,P＜0.05). ET of DN group showed significant elevation as compared with that of control group and DM group (P＜0.01,P＜0.01). Blood pressure of three group: DN group was higher, DM group was second, control group was lower.CGRP and ET were positively correlated in control group and DM group.CGRP and ET revealed no significant correlation in DN group.Conclusion: Blood pressure is influenced by the CGRP,in DM without blood vessel complication bigger than DN.