CAJ | 학술논문

目的探讨精神分裂症(SZ)的发病机制。方法　将 3 例慢性 SZ 患者尸体下丘脑组织进行光镜和电镜观察。结果　慢性 SZ 患者下丘脑部室管膜表面变性坏死、无细胞，病灶中有大量淀粉样小体和水肿，脉络丛血管扩张，管壁内膜有坏死和钙化；神经突触内大部分突触小泡和线粒体消失，部分前后膜模糊不清。结论　慢性 SZ 患者下丘脑神经突触中功能性组份减少，间接地证明了慢性 SZ 患者去甲肾上腺素(NE)、5-羟色胺(5-HT)、单胺氧化酶(MAO)活力降低。
목적탐토정신분렬증(SZ)적발병궤제。방법　장 3 례만성 SZ 환자시체하구뇌조직진행광경화전경관찰。결과　만성 SZ 환자하구뇌부실관막표면변성배사、무세포，병조중유대량정분양소체화수종，맥락총혈관확장，관벽내막유배사화개화；신경돌촉내대부분돌촉소포화선립체소실，부분전후막모호불청。결론　만성 SZ 환자하구뇌신경돌촉중공능성조빈감소，간접지증명료만성 SZ 환자거갑신상선소(NE)、5-간색알(5-HT)、단알양화매(MAO)활력강저。
Objective　To study the pathogenic mechanism of SZ.Methods　Hypothalamus tissues in bodies of 3 cases with SZ were observed on electron microscope and optical microscope.Results　Denatured necrosis occurred on the surface of hypothalamic periosteum with no cells and there was a large amount of starchy bodies and hydrops in foci with angiectasis of choroid plexus and necrosis and calcification in tunicaintima of vesicles,and mitochondria in the nerve synapse disappeared and part of anteroposterior membranes were blurred.Conclusion　The functional component in nerve synapse of hypothalamus decreases in cases with chronic SZ,which indirectly suggests that activity of noradrenalin,5-hydroxytryptamine and monoamine oxidase are reduced.