CAJ | 학술논문

合成了三种与卡铂空间结构类似的丙二酸银（Ⅰ）的化合物：〔Ag2(CH2(CO2)2)〕n(1),〔Ag2{(CH2)4C(CO2)2)}〕n(2)和〔Ag2{CH3CHCH2C(CO2)2}〕n(3)，并评价了它们对几种人类肿瘤细胞株的体外细胞毒性。所合成的化合物对实验用的几种肿瘤细胞株有强烈的毒性作用，而对正常人肝细胞的毒性作用则较弱，与肿瘤细胞株对比差异显著（P＜0.05）。虽然其作用机理还不清楚，但参照对铂类抗肿瘤药物的研究，本实验结果提示银的化合物也可能成为有希望的抗癌药物先导物。
합성료삼충여잡박공간결구유사적병이산은（Ⅰ）적화합물：〔Ag2(CH2(CO2)2)〕n(1),〔Ag2{(CH2)4C(CO2)2)}〕n(2)화〔Ag2{CH3CHCH2C(CO2)2}〕n(3)，병평개료타문대궤충인류종류세포주적체외세포독성。소합성적화합물대실험용적궤충종류세포주유강렬적독성작용，이대정상인간세포적독성작용칙교약，여종류세포주대비차이현저（P＜0.05）。수연기작용궤리환불청초，단삼조대박류항종류약물적연구，본실험결과제시은적화합물야가능성위유희망적항암약물선도물。
Threesilver(Ⅰ)compounds,〔Ag2(CH2(CO2)2)〕n(1),〔Ag2{(CH2)4C(CO2)2)}〕n (2)and〔Ag2{CH3CHCH2C(CO2)2}〕n(3 )were synthesized to be dimension analogues of the antitumor drug carboplatin and were evaluated for cytotoxic activity against several human cancer cell lines and normal cell lines.These compounds demonstrated significan t cytotoxic activities against a range of cancer cell lines while on the other h and they showed much lighter cytotoxity against a normal liver cell line(P＜ 0.0 5).The mechanism of their selective cytotoxicities remained unknown.Comparing to t he studies of Pt compounds,the results suggested that silver compounds might also be considered as a candidate for potential antitumor agents.