CAJ | 학술논문

目的我国广东省南澳县恙虫病发病率近年明显增高，而国内关于此疫源地的记录极少。本研究对该地区恙虫病疫源地进行全面研究。方法疫源地流行病学调查，病原分离鉴定与分子生物学研究，预防措施的制定。结果该地区为南亚热带岛屿疫源地，主要宿主为褐家鼠，主要媒介为地里纤恙螨，褐家鼠与地里纤恙螨的季节消长与发病均一致。从宿主与媒介分离到恙虫病立克次体经鉴定为Karp株。分子生物学结果与鉴定结果基本一致同时还证明存在Kato株与韩国地方株(Yonchon)。血清流行病学调查表明该地区居民与部队人群均存在恙虫病立克次体抗体。在流行季节前应用综合预防措施当年无病例发生。结论我国南澳县是恙虫病疫源地。
목적아국광동성남오현양충병발병솔근년명현증고，이국내관우차역원지적기록겁소。본연구대해지구양충병역원지진행전면연구。방법역원지류행병학조사，병원분리감정여분자생물학연구，예방조시적제정。결과해지구위남아열대도서역원지，주요숙주위갈가서，주요매개위지리섬양만，갈가서여지리섬양만적계절소장여발병균일치。종숙주여매개분리도양충병립극차체경감정위Karp주。분자생물학결과여감정결과기본일치동시환증명존재Kato주여한국지방주(Yonchon)。혈청류행병학조사표명해지구거민여부대인군균존재양충병립극차체항체。재류행계절전응용종합예방조시당년무병례발생。결론아국남오현시양충병역원지。
Aim Recent years the incidence of tsutsugamushi disease has increased on the Nan ao county in China and the characteristic of the epidemic area has not been reported. This study has investigated the region for the epidemic area of tsutsugamushi disease. Methods The investigation of the epidemic area,the isolation of Orientia tsutsugamushi,the study of pervention measures were carried out. Results The region is the island epidemic area of south subtropical zone. The main host is Rattus norvegicus. The main biological vector is Leptotrombidium (Leptotrombidium) deliens. The seasonal quantity trends of Rattus norvegicu and Leptotrombidium (Leptotrombidium) deliens are consistent with the incidence of the disease of the region. The Orientia tsutsugamushi has been isolated from Rattus norvegicus and Leptotrombidium (Leptotrombidium) deliens. The results of identification show that Orientia tsutsugamushi isolated strains is mainly Karp. The molcular biological resuits show that Kato and Korea strain (Yonchon) is present in the region. The serologic results show that antibody to Orientia tsutsugamushi is positive in the residents and army crowd. After the prevent measures were carried out,the incidence was descent. Conclusion The Nanao county is the epidemic area of tsutsugamushi disease.