CAJ | 학술논문

目的:观察芹灵颗粒(原芹灵冲剂)对慢性乙型肝炎患者的临床治疗效果。方法:将135例慢性乙型肝炎患者，分为芹灵颗粒治疗组90例；齐敦果酸片对照组45例，两组病例治疗前肝功能均不正常，HBsAg、HBeAg和抗-HBc均为阳性，症状体征均明显。治疗组芹灵冲剂1～2袋(相当生药10g/袋)，po，tid，30d为1疗程，2～3个疗程。对照组齐敦果酸片40mg，po，tid，疗程同治疗组。两组患者均于治疗2周复查肝功能和每疗程结束后检测乙肝病毒标志物一次。结果:治疗组90例慢性乙型肝炎经芹灵颗粒治疗后，基本治愈19例(21%)，有效64例(71%)，无效7例(8%)，总有效率为92.0%。降酶和退黄率分别为88%和83%，HBsAg、HBeAg和抗-HBc转阴率分别为21 %、53%和34%。对照组45例经齐敦果酸片治疗后，基本治愈6例(13%)，有效31例(69%)，无效8例(18%)，总有效率为82.0%。结论:芹灵颗粒具有改善慢性乙型肝炎患者的症状和体征、降低血中总胆红素和谷丙转氨酶的水平，对乙肝病毒标志物有一定转阴作用，临床疗效确切。
목적:관찰근령과립(원근령충제)대만성을형간염환자적림상치료효과。방법:장135례만성을형간염환자，분위근령과립치료조90례；제돈과산편대조조45례，량조병례치료전간공능균불정상，HBsAg、HBeAg화항-HBc균위양성，증상체정균명현。치료조근령충제1～2대(상당생약10g/대)，po，tid，30d위1료정，2～3개료정。대조조제돈과산편40mg，po，tid，료정동치료조。량조환자균우치료2주복사간공능화매료정결속후검측을간병독표지물일차。결과:치료조90례만성을형간염경근령과립치료후，기본치유19례(21%)，유효64례(71%)，무효7례(8%)，총유효솔위92.0%。강매화퇴황솔분별위88%화83%，HBsAg、HBeAg화항-HBc전음솔분별위21 %、53%화34%。대조조45례경제돈과산편치료후，기본치유6례(13%)，유효31례(69%)，무효8례(18%)，총유효솔위82.0%。결론:근령과립구유개선만성을형간염환자적증상화체정、강저혈중총담홍소화곡병전안매적수평，대을간병독표지물유일정전음작용，림상료효학절。
Aim To study the therapeutic effects of qinling keli on chronic hepatitis B.Methods Chronic hepatitis B patiens(N=90) were treated with qinling keli for 2～3 months.The liver function tests and serum HBsAg,HBeAg and anti-HBc of all cases were all abnormal before the treatment，with anorexia and general malaise.In therapeutic group,qinling keli 1～2 bags were given orally，three times a day for 1 month a course,usually for 2 to 3 courses.The liver function tests and serum HBsAg,HBeAg and anti-HBc were repeated after treatment.In control group,40mg Qidun Gosuan tablets，were given orally，three times a day for 1 month in therapeutic group.Results In therapeutic group: after 2～3 months treatment with qinling keli very effective results were obtained in 19 patients,improvement in 64 and ineffective in 7,with a total efficacy rate of 92%.The reduce ALT and bilirubin normalization rate were 88% and 83% after treatment,and negative rates of HBsAg,HBeAg and anti-HBc were 21%,53.3% and 34.4% in all patients respectively.The toxic and side effects were not found during administration.In control group:total efficacy rate of 82%.Conclusion QinLing keli can improved the symptom and physical sign,reduced ALT and normalize bilirubin. It may turned negative of HBsAg,HBeAg and anti-HBc.It is a safe and effective drug for chronic hepatitis B.