CAJ | 학술논문

目的：探讨 E-cadherin、α -catenin、β -catenin和γ -catenin与胃癌发生及胃癌生物学行为的关系。方法：用免疫组织化学方法检测 E-cadherin及α -catenin、β -catenin、γ -catenin在 43例胃癌， 22例胃癌前病变及 10例正常胃粘膜中的表达。结果：在胃癌前病变中 E-cadherin，α -catenin、β -catenin、γ -catenin的异常表达率分别为 22.7％、 22.7％、 18.2％、 27.3％，分别与胃癌 E-cadherin（ 53.5％），α -catenin（ 55.8％）、β -catenin（ 51.2％）的异常表达率相比差异有显著性（ P<0.05）。进展期胃癌异常表达率较早期胃癌高，除γ catenin外差异均有显著意义（ P< 0.05或 P< 0.01）。低分化胃癌 E cadherin的异常表达率较高，胃癌浸润到浆膜外及伴随淋巴结转移时 E cadherin、β catenin的异常表达率升高（ P< 0.05或 P< 0.01）。 76.7％的胃癌及 50.0％的胃癌前病变 E cadherin系统中至少有一项表达异常，二者差异有显著性（ P< 0.05），且至少有一项为表达异常病人的淋巴结转移率明显高于无蛋白异常表达者（ P< 0.01）。结论： E cadherin及部分相关蛋白的表达异常与胃癌的分化程度、临床分期、浸润深度及淋巴结转移密切相关， E cadherin系统在由胃不典型增生转化为胃癌的过程中起作用，联合检测 E cadherin及α catenin、β catenin、γ catenin可提高检测结果的参考价值。
목적：탐토 E-cadherin、α -catenin、β -catenin화γ -catenin여위암발생급위암생물학행위적관계。방법：용면역조직화학방법검측 E-cadherin급α -catenin、β -catenin、γ -catenin재 43례위암， 22례위암전병변급 10례정상위점막중적표체。결과：재위암전병변중 E-cadherin，α -catenin、β -catenin、γ -catenin적이상표체솔분별위 22.7％、 22.7％、 18.2％、 27.3％，분별여위암 E-cadherin（ 53.5％），α -catenin（ 55.8％）、β -catenin（ 51.2％）적이상표체솔상비차이유현저성（ P<0.05）。진전기위암이상표체솔교조기위암고，제γ catenin외차이균유현저의의（ P< 0.05혹 P< 0.01）。저분화위암 E cadherin적이상표체솔교고，위암침윤도장막외급반수림파결전이시 E cadherin、β catenin적이상표체솔승고（ P< 0.05혹 P< 0.01）。 76.7％적위암급 50.0％적위암전병변 E cadherin계통중지소유일항표체이상，이자차이유현저성（ P< 0.05），차지소유일항위표체이상병인적림파결전이솔명현고우무단백이상표체자（ P< 0.01）。결론： E cadherin급부분상관단백적표체이상여위암적분화정도、림상분기、침윤심도급림파결전이밀절상관， E cadherin계통재유위불전형증생전화위위암적과정중기작용，연합검측 E cadherin급α catenin、β catenin、γ catenin가제고검측결과적삼고개치。
Objective： The aim of this study was to evaluate the expression of E-cadherin,α -catenin,β -catenin,and γ -catenin in gastric carcinoma and dysplasia and to determine the relationship with tumorigenesis and biological behavior of gastric cancer. Methods： The expression of E-cadherin, α -catenin, β -catenin, and γ -catenin in 43 patients with gastric carcinoma and gastric biopsy specimens from 22 patients with dysplasia and 10 healthy controls were determined using immunohistochemistry. Results： Membranous staining was observed in control biopsy specimens for all components of the complex. Abnormal expressive rates of E-cadherin,α -catenin,β -catenin in gastric carcinomas (53.5％ ,55.8％ ,51.2％ ,respectively) were significantly higher than that in gastric mucosal dysplasials （ 22.7％ ,22.7％ , 18.2％ , respectively P<0.05） ,and the rates in advanced gastric carcinomas were also significantly higher than that in early gastric carcinoma（ P< 0.01, P< 0.05, P< 0.01,respectively） . Tumors with a decrease in E cadherin occurred significantly more frequently in undifferentiated gastric carcinoma (P< 0.05). There were higher abnormal expressive rates of E-cadherin and β  catenin in the patients with tumor infiltrating out of serosa and with lymph nodes metastasis （ P<0.01 or P< 0.05） . Up to 50.0％ of gastric dysplasials and 76.7％ of tumors stained abnormally for one or more components of the cadherin catenin complex (P< 0.05), and the lymph nodes metastasis rates for one or more components of the E cadherin complex was significantly higher than that for no one components of the E cadherin complex (P< 0.01). Conclusion： The decreased expression of E cadherin and part of the catenins correlate with tumor stage, poor differentiation, infiltrative tumor growth, and lymph nodes metastasis, which suggests that E cadherin complex play a critical role in the course of chang from gastric mucosal dysplasials to gastric carcinoma. Thus, study of all the components of E cadherin catenin complex may be more valuable than single component of the complex for the detection of patients with gastric carcinoma.