CAJ | 학술논문

目的：探讨血清新蝶呤与鼻咽癌的关系及临床意义。方法：采用ELISA竞争法检测54例初治鼻咽低分化鳞癌(鼻咽癌组)治疗前、后及32例健康成人(对照组)的血清新蝶呤水平。结果：鼻咽癌组新蝶呤浓度明显高于对照组(P<0.01)。各TNM分期之间新蝶呤水平无差异(P>0.05)。无淋巴结转移者血清新蝶呤浓度低于有淋巴结转移者(P<0.05)。治疗后新蝶呤水平比治疗前明显降低(P<0.01)，但仍比对照组高(P<0.01)；治疗后6个月病灶全消者新蝶呤水平仍维持较低水平而病灶部分残留者复又上升(P<0.01)。结论：鼻咽癌病理发生过程中可能存在着巨噬细胞介导的细胞免疫过激或免疫应答异常；血清新蝶呤水平动态观察可作为鼻咽癌病情评估和疗效监测的一项客观指标。
목적：탐토혈청신접령여비인암적관계급림상의의。방법：채용ELISA경쟁법검측54례초치비인저분화린암(비인암조)치료전、후급32례건강성인(대조조)적혈청신접령수평。결과：비인암조신접령농도명현고우대조조(P<0.01)。각TNM분기지간신접령수평무차이(P>0.05)。무림파결전이자혈청신접령농도저우유림파결전이자(P<0.05)。치료후신접령수평비치료전명현강저(P<0.01)，단잉비대조조고(P<0.01)；치료후6개월병조전소자신접령수평잉유지교저수평이병조부분잔류자복우상승(P<0.01)。결론：비인암병리발생과정중가능존재착거서세포개도적세포면역과격혹면역응답이상；혈청신접령수평동태관찰가작위비인암병정평고화료효감측적일항객관지표。
Objective:To evaluate the relationship between serum neopterin levels and nasopharyngeal carcinoma and its clinical significance. Method:The serum neopterin levels were determined in 54 patients with nasopharyngeal carcinoma (NPC group) and 32 healthy adults (normal group) by ELISA. Result:The serum neopterin levels in NPC group were significantly higher than that of in normal group (P<0.001). The serum neopterin levels in UICC-TNM stages were undifferentiated (P>0.05). The serum neopterin levels in patients with no lymph node metastasis were lower than that of in lymph node metastasis (P<0.05). The serum neopterin levels decreased significantly after disappearance of tumor and its lymph node treated by radiotherapy (P<0.01). Conclusion:Cellular immunity mediated by macrophages might be involved in the pathologenesis of nasopharyngeal carcinoma and the measurement of the serum neopterin may be a useful objective index to evaluate cellular immunological functions and curative effects.