CAJ | 학술논문

缺血后处理是在长时间缺血后再灌注早期对心脏进行数次短暂的再灌注/缺血处理的方法.它是缺血心脏有效的内源性保护现象,可以减轻缺血/再灌注后心肌坏死与功能障碍,减少恶性心律失常的发生.人们对其发生机理、信号通路以及潜在的临床应用等方面已作了较多研究.现对缺血后处理的特征、心肌保护作用、分子机制以及临床应用前景作一综述.
결혈후처리시재장시간결혈후재관주조기대심장진행수차단잠적재관주/결혈처리적방법.타시결혈심장유효적내원성보호현상,가이감경결혈/재관주후심기배사여공능장애,감소악성심률실상적발생.인문대기발생궤리、신호통로이급잠재적림상응용등방면이작료교다연구.현대결혈후처리적특정、심기보호작용、분자궤제이급림상응용전경작일종술.
Ischemic postconditioning (I-postC) is defined as a procedure of rapid intermittent periods of reperfusion and ischemia in the early phase of reperfusion after long ischemia. I-postC is the endogenous protective mechanism capable of protecting the myocardium from myocardial necrosis, dysfunction, and vicious ventricular arrhythmia induced by ischemia/reperfusion (I/R) injury. Research has been done on its mechanism, signaling pathways, and potential clinical applications. This review will cover the characteristics, cardioprotective effects, molecular mechanism, and potential applications of I-postC.