CAJ | 학술논문

目的通过多因素分析,筛选出与2型糖尿病患者伴发口腔假丝酵母菌感染密切相关的指标,建立预测方程,分析2型糖尿病患者口腔假丝酵母菌感染的危险因素.方法选择140例2型糖尿病患者,记录性别,年龄,病程,吸烟史,空腹血糖值及系统并发症(包括肾病、神经病变和高血压);并对患者进行口腔检查,记录口腔卫生状况、口腔黏膜情况及义齿修复情况.运用标准含漱浓缩法检测患者口腔假丝酵母菌的检出率和负载量,并采用CHROM agar显色培养基进行初步生物分型.应用Logistic回归分析方法研究2型糖尿病患者口腔假丝酵母菌感染与上述11项临床指标之间的关系.结果 140例2型糖尿病患者中有69例检出口腔假丝酵母菌,检出率为49.3%,检出的假丝酵母菌菌种以白假丝酵母菌为主.以上述11项临床指标作为自变量,口腔假丝酵母菌感染发生与否作为因变量,进行Logistic回归分析,建立Logistic回归方程,方程的总判断率为82.1%.经回归分析,空腹血糖值、口腔卫生状况和黏膜干燥是2型糖尿病患者伴发口腔假丝酵母菌感染的危险因素.结论空腹血糖值、口腔卫生状况、黏膜干燥是2型糖尿病患者伴发口腔假丝酵母菌感染的危险因素;通过同归方程得出的概率值可为2型糖尿病患者口腔假丝酵母菌感染的预测及口腔护理保健提供参考.
목적 통과다인소분석,사선출여2형당뇨병환자반발구강가사효모균감염밀절상관적지표,건립예측방정,분석2형당뇨병환자구강가사효모균감염적위험인소.방법 선택140례2형당뇨병환자,기록성별,년령,병정,흡연사,공복혈당치급계통병발증(포괄신병、신경병변화고혈압);병대환자진행구강검사,기록구강위생상황、구강점막정황급의치수복정황.운용표준함수농축법검측환자구강가사효모균적검출솔화부재량,병채용CHROM agar현색배양기진행초보생물분형.응용Logistic회귀분석방법연구2형당뇨병환자구강가사효모균감염여상술11항림상지표지간적관계.결과 140례2형당뇨병환자중유69례검출구강가사효모균,검출솔위49.3%,검출적가사효모균균충이백가사효모균위주.이상술11항림상지표작위자변량,구강가사효모균감염발생여부작위인변량,진행Logistic회귀분석,건립Logistic회귀방정,방정적총판단솔위82.1%.경회귀분석,공복혈당치、구강위생상황화점막간조시2형당뇨병환자반발구강가사효모균감염적위험인소.결론 공복혈당치、구강위생상황、점막간조시2형당뇨병환자반발구강가사효모균감염적위험인소;통과동귀방정득출적개솔치가위2형당뇨병환자구강가사효모균감염적예측급구강호리보건제공삼고.
Objective Multivariate analysis was used to select the risk factors in non-insulin dependent diabetes mellitus (NIDDM) patients with oral candidosis, and to establish the forecasting equation, aimed to detect the risk of oral candidosis among NIDDM patients. Methods 140 NIDDM patients were included in this study. 11 clinical pa rameters including gender, age, course smoking, fasting blood glucose, oral hygiene status, systemic manifestation, oral mucous membrane status, and denture were recorded respectively. Oral rinse technique was used to detect the salivary candidal carriage. The isolates were identified using CHROM agar Candida test. The Logistic multivariate regression analysis was carried our for risk factors analysis. Results Candida was found in 69 out of 140 NIDDM cases, and Candida albicans was the major species isolated. The poor glycemic control, poor oral hygiene, and dry mouth were the risk factors of oral candidosis in NIDDM patients, and the forecasting equation was established. Using substitution method, the veracity of the forecasting equation was 82.1%. Conclusion Poor glycemic control, poor oral hygiene and dry mouth were risk factors of oral candidosis among NIDDM patients. The probability obtained from the forecasting equation may offer references for predicting and preventing the oral candidosis in NIDDM patients.