中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
15期
33-36,37
,共5页
骨质疏松%大鼠%骨折愈合%雷尼酸锶%强骨胶囊
骨質疏鬆%大鼠%骨摺愈閤%雷尼痠鍶%彊骨膠囊
골질소송%대서%골절유합%뢰니산송%강골효낭
Osteoporosis%Rats%Fracture healing%Strontium ranelate%Qianggu capsule
目的：通过观察雷尼酸锶联合强骨胶囊对骨质疏松性骨折愈合的影响，以探讨中西医结合治疗骨质疏松性骨折的意义。方法：30只SD大鼠给予维甲酸灌胃，制造骨质疏松性骨折模型成功后，按随机数字表分为实验组和对照组，每组15只。实验组给予雷尼酸锶联合强骨胶囊灌胃，对照组给予生理盐水灌胃，于2周、4周和6周处死实验鼠，进行骨痂大小的测量及组织学研究。结果：2周时两组骨痂大小比较差异无统计学意义（P>0.05）；4周时实验组骨痂大小较对照组小，差异有统计学意义（P<0.05）；6周时实验组骨痂大小明显小于对照组，差异有统计学意义（P<0.01）。2周时组织学检测发现，实验组成骨细胞数目较对照组无明显增多；4周及6周时则明显增多。结论：雷尼酸锶联合强骨胶囊治疗维甲酸所致大鼠骨质疏松性骨折疗效显著。
目的：通過觀察雷尼痠鍶聯閤彊骨膠囊對骨質疏鬆性骨摺愈閤的影響，以探討中西醫結閤治療骨質疏鬆性骨摺的意義。方法：30隻SD大鼠給予維甲痠灌胃，製造骨質疏鬆性骨摺模型成功後，按隨機數字錶分為實驗組和對照組，每組15隻。實驗組給予雷尼痠鍶聯閤彊骨膠囊灌胃，對照組給予生理鹽水灌胃，于2週、4週和6週處死實驗鼠，進行骨痂大小的測量及組織學研究。結果：2週時兩組骨痂大小比較差異無統計學意義（P>0.05）；4週時實驗組骨痂大小較對照組小，差異有統計學意義（P<0.05）；6週時實驗組骨痂大小明顯小于對照組，差異有統計學意義（P<0.01）。2週時組織學檢測髮現，實驗組成骨細胞數目較對照組無明顯增多；4週及6週時則明顯增多。結論：雷尼痠鍶聯閤彊骨膠囊治療維甲痠所緻大鼠骨質疏鬆性骨摺療效顯著。
목적：통과관찰뢰니산송연합강골효낭대골질소송성골절유합적영향，이탐토중서의결합치료골질소송성골절적의의。방법：30지SD대서급여유갑산관위，제조골질소송성골절모형성공후，안수궤수자표분위실험조화대조조，매조15지。실험조급여뢰니산송연합강골효낭관위，대조조급여생리염수관위，우2주、4주화6주처사실험서，진행골가대소적측량급조직학연구。결과：2주시량조골가대소비교차이무통계학의의（P>0.05）；4주시실험조골가대소교대조조소，차이유통계학의의（P<0.05）；6주시실험조골가대소명현소우대조조，차이유통계학의의（P<0.01）。2주시조직학검측발현，실험조성골세포수목교대조조무명현증다；4주급6주시칙명현증다。결론：뢰니산송연합강골효낭치료유갑산소치대서골질소송성골절료효현저。
Objective:To explore the significance of treatment of combining traditional Chinese and western medicine on osteoporotic fracture,and to observe the effect of Strontium ranelate combined with Qianggu capsule on osteoporotic fracture healing. Method:30 spragne-dawley rats were given with the retinoie acid intragastrically to induce osteoporosis.All rats with osteoporosis were randomly divided into the experimental group and the control group,each group had 15 rats,the experimental group and the control group were respectively given Strontium ranelate combined with Qianggu capsule and normal saline. The rats in each group were sacrificed at the second,fourth and sixth week respectively. Size of bony callus was measured and histopathologic features were analyzed.Result:There was no significant difference of the size of bony callus between two groups at the second week(P>0.05). At the fourth week,the experimental group’s bony callus was smaller than the control group and there was significant difference between two groups (P<0.05). At the sixth week,the experimental group’s bony callus was obviously smaller than the control group and there was significant difference between two groups(P<0.01). At the second week,histological inspection found that compared with the control group,there was no significant increased of osteoblast number in the experimental group,but at the fourth week and the sixth week,there was significant increased. Conclusion:Strontium ranelate combined with Qianggu capsule has obviously curative effect on osteoporotic fracture rats caused by retinoie acid.
