国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2012年
2期
79-85
,共7页
颞叶癫痫%脑电图%δ频段%Granger因果分析%功能连接
顳葉癲癇%腦電圖%δ頻段%Granger因果分析%功能連接
섭협전간%뇌전도%δ빈단%Granger인과분석%공능련접
Temporal lobe epilepsy%Electroencephalograph%δ-bands%Granger causality analysis%Functional connectivity
目的 应用频域Granger因果分析方法,研究颞叶癫痫发作间歇期16导脑电图(EEG)在与癫痫发作相关的δ频段的过度放电功能连接特性.方法 实验数据来自颞叶癫痫9例患者(6例左颞叶癫痫,3例右颞叶癫痫),9例正常对照受试者.记录每例颞叶癫痫受试者在发作间歇期的痫样放电、非痫样放电以及正常对照组的共3个状态的16导EEG;每个状态下各记录10个EEG数据段,每个数据段长度为20s,采样频率为200 Hz;应用带通滤波提取EEG的δ分量(1～4 Hz).应用频域Granger因果分析方法,分别计算痫样放电组、非痫样放电组和正常组10次记录的16通道EEGδ频段分量之间的频域因果度量平均值Iδ；分析以上3个组颞叶区(左颞叶癫痫:T3、T5,右颞叶癫痫:T4、T6)与额区(Fp1、Fp2、F3、F4)和顶区(C3、C4)之间EEG在δ频段的功能连接模式.结果 痫样放电组:下颞叶区(左下颞叶区T5,右下颞叶区T6)与额区、顶区之间Iδ在0.1323±0.0329～0.1670±0.0289；非痫样放电组:下颞叶区与额区、顶区之间的Iδ在0.0300±0.0130～0.0420±0.0072；正常对照组:下颞叶区与额区、顶区之间的Iδ在0.0153±0.0028～0.0193±0.0057.统计结果表明:痫样放电组下颞叶区与额区、顶区之间的Iδ值与非痫样放电组相比差异有统计学意义(P＜0.05),与正常对照组相比差异有统计学意义(P＜0.01)；非痫样放电组下颞叶区与额叶、顶叶之间的Iδ值和正常对照组相比差异无统计学意义(P＞0.05).结论 颞叶癫痫发作间歇期在痫样放电状态下,EEGδ频段在下颞叶区与额区、顶区之间存在较强连接,过度放电从下颞叶区传递到额区和顶区.非痫样放电组和正常组的EEGδ频段,下颞叶区与额叶、顶叶之间连接弱,下颞叶区不是EEG信号传导的起始区.
目的 應用頻域Granger因果分析方法,研究顳葉癲癇髮作間歇期16導腦電圖(EEG)在與癲癇髮作相關的δ頻段的過度放電功能連接特性.方法 實驗數據來自顳葉癲癇9例患者(6例左顳葉癲癇,3例右顳葉癲癇),9例正常對照受試者.記錄每例顳葉癲癇受試者在髮作間歇期的癇樣放電、非癇樣放電以及正常對照組的共3箇狀態的16導EEG;每箇狀態下各記錄10箇EEG數據段,每箇數據段長度為20s,採樣頻率為200 Hz;應用帶通濾波提取EEG的δ分量(1～4 Hz).應用頻域Granger因果分析方法,分彆計算癇樣放電組、非癇樣放電組和正常組10次記錄的16通道EEGδ頻段分量之間的頻域因果度量平均值Iδ；分析以上3箇組顳葉區(左顳葉癲癇:T3、T5,右顳葉癲癇:T4、T6)與額區(Fp1、Fp2、F3、F4)和頂區(C3、C4)之間EEG在δ頻段的功能連接模式.結果 癇樣放電組:下顳葉區(左下顳葉區T5,右下顳葉區T6)與額區、頂區之間Iδ在0.1323±0.0329～0.1670±0.0289；非癇樣放電組:下顳葉區與額區、頂區之間的Iδ在0.0300±0.0130～0.0420±0.0072；正常對照組:下顳葉區與額區、頂區之間的Iδ在0.0153±0.0028～0.0193±0.0057.統計結果錶明:癇樣放電組下顳葉區與額區、頂區之間的Iδ值與非癇樣放電組相比差異有統計學意義(P＜0.05),與正常對照組相比差異有統計學意義(P＜0.01)；非癇樣放電組下顳葉區與額葉、頂葉之間的Iδ值和正常對照組相比差異無統計學意義(P＞0.05).結論 顳葉癲癇髮作間歇期在癇樣放電狀態下,EEGδ頻段在下顳葉區與額區、頂區之間存在較彊連接,過度放電從下顳葉區傳遞到額區和頂區.非癇樣放電組和正常組的EEGδ頻段,下顳葉區與額葉、頂葉之間連接弱,下顳葉區不是EEG信號傳導的起始區.
목적 응용빈역Granger인과분석방법,연구섭협전간발작간헐기16도뇌전도(EEG)재여전간발작상관적δ빈단적과도방전공능련접특성.방법 실험수거래자섭협전간9례환자(6례좌섭협전간,3례우섭협전간),9례정상대조수시자.기록매례섭협전간수시자재발작간헐기적간양방전、비간양방전이급정상대조조적공3개상태적16도EEG;매개상태하각기록10개EEG수거단,매개수거단장도위20s,채양빈솔위200 Hz;응용대통려파제취EEG적δ분량(1～4 Hz).응용빈역Granger인과분석방법,분별계산간양방전조、비간양방전조화정상조10차기록적16통도EEGδ빈단분량지간적빈역인과도량평균치Iδ；분석이상3개조섭협구(좌섭협전간:T3、T5,우섭협전간:T4、T6)여액구(Fp1、Fp2、F3、F4)화정구(C3、C4)지간EEG재δ빈단적공능련접모식.결과 간양방전조:하섭협구(좌하섭협구T5,우하섭협구T6)여액구、정구지간Iδ재0.1323±0.0329～0.1670±0.0289；비간양방전조:하섭협구여액구、정구지간적Iδ재0.0300±0.0130～0.0420±0.0072；정상대조조:하섭협구여액구、정구지간적Iδ재0.0153±0.0028～0.0193±0.0057.통계결과표명:간양방전조하섭협구여액구、정구지간적Iδ치여비간양방전조상비차이유통계학의의(P＜0.05),여정상대조조상비차이유통계학의의(P＜0.01)；비간양방전조하섭협구여액협、정협지간적Iδ치화정상대조조상비차이무통계학의의(P＞0.05).결론 섭협전간발작간헐기재간양방전상태하,EEGδ빈단재하섭협구여액구、정구지간존재교강련접,과도방전종하섭협구전체도액구화정구.비간양방전조화정상조적EEGδ빈단,하섭협구여액협、정협지간련접약,하섭협구불시EEG신호전도적기시구.
Objective The purpose of this research was to investigate functional connectivity of 16-channel electroencephalograph(EEG) in δ frequency band based on Granger causality analysis.Methods The experimental data was recorded at a sampling rate of 200 Hz from temporal lobe epilepsy (TLE) patients(6 left and 3 right TLE,and 9 normals as control group.Ten of EEG segments of 20 s length for three different states:epileptiform discharges (ED) state in interictal durations,non-ED state for TLE patients,and control state for the normal.The δ band components (1～4 Hz) were filtered from EEGs.The functional connection values Iδ between two EEG δ components were calculated separately by Granger causality analysis.The two EEG components were from inferoposterior temporal lobe (left:T5,right:T6) to frontal lobe (Fp1,Fp2,F3,F4,and parietal lobe (C3,C4) for three states.Results The Iδ values for ED state was 0.1323±0.0329～0.1670±0.028 9,which was significantly higher than that of non-ED state (0.0300±0.0130～0.0420±0.0072) (P＜0.05).The Iδ values for the control group (0.0153±0.0028～0.0193±0.0057) was much lower than that of ED state (P＜0.01),and no obvious distinctions were observed compared with non-ED state at P=0.05 level.Conclusion There is a stronger connection of EEG' s δ bands from the inferoposterior temporal lobe to frontal and parietal lobe for the ED state,and the over-discharges transmission is from inferoposterior temporal lobe to other brain regions.There is a weaker connection from the top temporal lobe to frontal and parietal lobe for non-ED state and control group,and the onset zones is not inferoposterior temporal lobe.
