CAJ | 학술논문

骨桥蛋白是一种分泌性磷酸化糖蛋白,功能上具有细胞因子的特点,广泛存在于多种组织细胞中.骨桥蛋白能促进Th1型反应、刺激角质形成细胞增生,参与细胞的趋化、聚集、黏附和迁移、增殖和抗凋亡、促进血管新生,免疫调节、信号转导等多种生物学过程,在炎症反应、自身免疫性疾病以及银屑病的发生发展中起作用.从骨桥蛋白的结构、生物学特性,以及与银屑病的关系方面进行概述.对骨桥蛋白进行深入研究,将对认识银屑病发病机制和治疗提供新的思路.
골교단백시일충분비성린산화당단백,공능상구유세포인자적특점,엄범존재우다충조직세포중.골교단백능촉진Th1형반응、자격각질형성세포증생,삼여세포적추화、취집、점부화천이、증식화항조망、촉진혈관신생,면역조절、신호전도등다충생물학과정,재염증반응、자신면역성질병이급은설병적발생발전중기작용.종골교단백적결구、생물학특성,이급여은설병적관계방면진행개술.대골교단백진행심입연구,장대인식은설병발병궤제화치료제공신적사로.
As a secreted phosphorylated glycoprotein,osteopontin exists in many tissue cells and exerts cytokine-like functions.For example,osteopontin can enhance Th1 type response,promote keratinocyte proliferation and angiogenesis,mediate cell chemotaxis,aggregation,adhesion,migration,invasion,antiapoptotic response,immunoregulation,signal transduction,etc,and play a certain role in the initiation and progression of inflammatory reaction,autoimmune diseases and psoriasis.This review presents the structure,biological characters of osteopontin and its relationship with psoriasis.Further study on osteopontin may offer new clues to the understanding of pathogenesis of and to the development of therapeutic intervention for psoriasis.