国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2008年
6期
426-427
,共2页
神经生长因子%肝%纤维化
神經生長因子%肝%纖維化
신경생장인자%간%섬유화
Nerve growth factor%Liver%Fibrosis
肝星形细胞(HSC)活化是肝纤维化形成的关键因素.目前研究显示,神经生长因子(NGF)可能通过抑制肝脏炎症,诱导活化的HSC凋亡,进而减缓肝纤维化的进展,其作用机制可能包括NGF及其低亲和力受体P75的作用.诱导活化HSC凋亡将是治疗和逆转肝纤维化的理想途径.
肝星形細胞(HSC)活化是肝纖維化形成的關鍵因素.目前研究顯示,神經生長因子(NGF)可能通過抑製肝髒炎癥,誘導活化的HSC凋亡,進而減緩肝纖維化的進展,其作用機製可能包括NGF及其低親和力受體P75的作用.誘導活化HSC凋亡將是治療和逆轉肝纖維化的理想途徑.
간성형세포(HSC)활화시간섬유화형성적관건인소.목전연구현시,신경생장인자(NGF)가능통과억제간장염증,유도활화적HSC조망,진이감완간섬유화적진전,기작용궤제가능포괄NGF급기저친화력수체P75적작용.유도활화HSC조망장시치료화역전간섬유화적이상도경.
Activation of hepatic stellate cell (HSC) is the critical factor in hepatic fibrosis emerged. Recently, the research has displayed that nerve grouth foctor(NGF) may inhibit liver inflammation to induce apoptosis of activated HSC and to slow down the progress of hepatic fibrosis. The mechanisms may include the effect of NGF and P75. It is an effectual path to treat and reverse hepatic fibrosis inducing apoptosis of activated HSC.
