中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
27期
11-13
,共3页
俞立农%郝建%彭晓露%沈亚伟%黄鹤
俞立農%郝建%彭曉露%瀋亞偉%黃鶴
유립농%학건%팽효로%침아위%황학
肺疾病%慢性阻塞性%内皮缩血管肽类%血气分析%肺功能
肺疾病%慢性阻塞性%內皮縮血管肽類%血氣分析%肺功能
폐질병%만성조새성%내피축혈관태류%혈기분석%폐공능
Pulmonary disease,chronic obstructive%Endothelins%Blood gas analysis%Pulmonary function
目的 探讨慢性阻塞性肺疾病(COPD)患者血浆内皮素(ET)-1含量与肺功能变化的关系.方法 选择健康体检者30例为A组,选择34例COPD急性发作期患者为B组,患者治疗后病情缓解期为C组,分别在治疗前后测定血浆ET-1含量,并行动脉血气及肺功能检查.结果 B、C组患者血浆ET-1含量显著高于A组,与PaO2:呈负相关,且与PaCO2呈正相关,P值均＜0.01.B组患者肺功能参数(VC、FEV1/FVC、MVV、V50、V25)明显低于A组和C组[分别为(55.3±24.5)%、(54.8±19.3)%、(54.2± 416.2)%、(54.8±9.9)%、(58.7±14.5)%与(114.8±24.1)%、(84.9±21.6)%、(86.4 ±17、2)%、(78.5±14.8)%、(90、3.±15.4)%和(110.1±19.4)%、(85.8 ±15.5)%、(85.9 ±16.7)%、(74.5±13.4)%、(89.4±18.6)%],P值均＜0.01.结论 血浆ET-1、缺氧、CO2:潴留共同参与COPD病理生理的调节作用,从而影响肺功能变化.
目的 探討慢性阻塞性肺疾病(COPD)患者血漿內皮素(ET)-1含量與肺功能變化的關繫.方法 選擇健康體檢者30例為A組,選擇34例COPD急性髮作期患者為B組,患者治療後病情緩解期為C組,分彆在治療前後測定血漿ET-1含量,併行動脈血氣及肺功能檢查.結果 B、C組患者血漿ET-1含量顯著高于A組,與PaO2:呈負相關,且與PaCO2呈正相關,P值均＜0.01.B組患者肺功能參數(VC、FEV1/FVC、MVV、V50、V25)明顯低于A組和C組[分彆為(55.3±24.5)%、(54.8±19.3)%、(54.2± 416.2)%、(54.8±9.9)%、(58.7±14.5)%與(114.8±24.1)%、(84.9±21.6)%、(86.4 ±17、2)%、(78.5±14.8)%、(90、3.±15.4)%和(110.1±19.4)%、(85.8 ±15.5)%、(85.9 ±16.7)%、(74.5±13.4)%、(89.4±18.6)%],P值均＜0.01.結論 血漿ET-1、缺氧、CO2:潴留共同參與COPD病理生理的調節作用,從而影響肺功能變化.
목적 탐토만성조새성폐질병(COPD)환자혈장내피소(ET)-1함량여폐공능변화적관계.방법 선택건강체검자30례위A조,선택34례COPD급성발작기환자위B조,환자치료후병정완해기위C조,분별재치료전후측정혈장ET-1함량,병행동맥혈기급폐공능검사.결과 B、C조환자혈장ET-1함량현저고우A조,여PaO2:정부상관,차여PaCO2정정상관,P치균＜0.01.B조환자폐공능삼수(VC、FEV1/FVC、MVV、V50、V25)명현저우A조화C조[분별위(55.3±24.5)%、(54.8±19.3)%、(54.2± 416.2)%、(54.8±9.9)%、(58.7±14.5)%여(114.8±24.1)%、(84.9±21.6)%、(86.4 ±17、2)%、(78.5±14.8)%、(90、3.±15.4)%화(110.1±19.4)%、(85.8 ±15.5)%、(85.9 ±16.7)%、(74.5±13.4)%、(89.4±18.6)%],P치균＜0.01.결론 혈장ET-1、결양、CO2:저류공동삼여COPD병리생리적조절작용,종이영향폐공능변화.
Objective To explore the relationship of content of plasma endothelin(ET)-1 with the change of pulmonary function in patients with chronic obstructive pulmonary disease(COPD).Method Thirty cases of the normal people were as group A ,34 cases of the patients with COPD with acute exacerbation before treatment were as group B and the patients with remission period after treatment were as group C,the plasma ET-1,arterial blood gas and pulmonary function parameters were determined from the patients before and after treatment.Results The plasma ET-1 in group B and group C were significantly higher than that in group A,the content of the plasma ET-1 had negatively correlated with PaO2,and that had positively correlated with PaCO2,P＜0.01.The pulmonary function parameters (VC,FEV1/FVC,MVV,V50 V25)in group B were significantly lower than those in group A and group C[(55.3±24.5)%,(54.8±19.3)%,(54.2±16.2)%,(54,8±9,9)%,(58.7±14.5)%;(114.8±24.1)%,(84.9±21.6)%,(86.4±17.2)%,(78.5±14.8)%,(90.3±15.4)% and (110.1±19.4)%,(85.8±15.5)%,(85.9±16.7)%,(74.5±13.4)%,(89.4±18.6)%,respectively],P＜0.01.Conclusion Pathophysiological effects of patients with COPD can be commonly adjusted by the plasma ET-1,oxygen and carbon dioxide retention,which affect pulmonary function.
