中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2012年
5期
316-319
,共4页
宓余强%刘勇钢%徐亮%范建高%张弘%平蕾%董红筠%石瑞芳
宓餘彊%劉勇鋼%徐亮%範建高%張弘%平蕾%董紅筠%石瑞芳
복여강%류용강%서량%범건고%장홍%평뢰%동홍균%석서방
肝炎,乙型,慢性%脂肪肝%肝炎表面抗原,乙型%肝炎核心抗原,乙型%免疫组织化学
肝炎,乙型,慢性%脂肪肝%肝炎錶麵抗原,乙型%肝炎覈心抗原,乙型%免疫組織化學
간염,을형,만성%지방간%간염표면항원,을형%간염핵심항원,을형%면역조직화학
Hepatitis B,chronic%Fatty liver%Hepatitis B surface antigens%Hepatitis B core antigens%Immunohistochemistry
目的 探讨慢性乙型肝炎(CHB)患者肝细胞脂肪变与肝脏HBsAg和HBcAg表达的关系.方法 选取2005年1月至2008年6月间天津市传染病医院经肝活组织检查确诊的CHB合并肝脂肪变患者147例,另选取与其血清HBV DNA接近的无肝脂肪变的CHB患者149例,比较2组肝脏HBsAg、HBcAg免疫组织化学染色及肝脏损伤的差异.统计分析采用t检验和x2检验.结果 与无肝脂肪变组相比,肝脂肪变组平均年龄和体质指数较高(t值分别=-3.31和-6.57,P值均＜0.01),肝组织中重度炎性反应、明显纤维化及HBsAg强阳性染色的比例则较低(分别为30.6％比15.4％、26.5％比12.8％、23.1％比6.7％,x2值分别=9.63、8.92、15.76,P值均＜0.01),HBcAg强阳性染色比例亦呈下降趋势.与肝脂肪变程度F1至F2级者比较,F3至F4级者肝脏HBsAg、HBcAg强阳性染色比例呈下降趋势.结论 肝脂肪变影响CHB患者肝组织内HBsAg、HBcAg的表达,随肝脂肪变的出现及加重,HBsAg、HBcAg表达及肝组织损伤程度均呈下降趋势.
目的 探討慢性乙型肝炎(CHB)患者肝細胞脂肪變與肝髒HBsAg和HBcAg錶達的關繫.方法 選取2005年1月至2008年6月間天津市傳染病醫院經肝活組織檢查確診的CHB閤併肝脂肪變患者147例,另選取與其血清HBV DNA接近的無肝脂肪變的CHB患者149例,比較2組肝髒HBsAg、HBcAg免疫組織化學染色及肝髒損傷的差異.統計分析採用t檢驗和x2檢驗.結果 與無肝脂肪變組相比,肝脂肪變組平均年齡和體質指數較高(t值分彆=-3.31和-6.57,P值均＜0.01),肝組織中重度炎性反應、明顯纖維化及HBsAg彊暘性染色的比例則較低(分彆為30.6％比15.4％、26.5％比12.8％、23.1％比6.7％,x2值分彆=9.63、8.92、15.76,P值均＜0.01),HBcAg彊暘性染色比例亦呈下降趨勢.與肝脂肪變程度F1至F2級者比較,F3至F4級者肝髒HBsAg、HBcAg彊暘性染色比例呈下降趨勢.結論 肝脂肪變影響CHB患者肝組織內HBsAg、HBcAg的錶達,隨肝脂肪變的齣現及加重,HBsAg、HBcAg錶達及肝組織損傷程度均呈下降趨勢.
목적 탐토만성을형간염(CHB)환자간세포지방변여간장HBsAg화HBcAg표체적관계.방법 선취2005년1월지2008년6월간천진시전염병의원경간활조직검사학진적CHB합병간지방변환자147례,령선취여기혈청HBV DNA접근적무간지방변적CHB환자149례,비교2조간장HBsAg、HBcAg면역조직화학염색급간장손상적차이.통계분석채용t검험화x2검험.결과 여무간지방변조상비,간지방변조평균년령화체질지수교고(t치분별=-3.31화-6.57,P치균＜0.01),간조직중중도염성반응、명현섬유화급HBsAg강양성염색적비례칙교저(분별위30.6％비15.4％、26.5％비12.8％、23.1％비6.7％,x2치분별=9.63、8.92、15.76,P치균＜0.01),HBcAg강양성염색비례역정하강추세.여간지방변정도F1지F2급자비교,F3지F4급자간장HBsAg、HBcAg강양성염색비례정하강추세.결론 간지방변영향CHB환자간조직내HBsAg、HBcAg적표체,수간지방변적출현급가중,HBsAg、HBcAg표체급간조직손상정도균정하강추세.
Objective To explore the association between hepatic steatosis and the liver tissue expression of HBsAg and HBcAg in chronic hepatitis B (CHB) patients.Methods From January 2005 to June 2008,a total of 147 CHB patients with hepatic steatosis diagnosed by liver biopsy and other 149 CHB patients without hepatic steatosis but with similar HBV DNA titer were enrolled.The differences of HBsAg and HBcAg immunostaining and liver injury in these two groups were compared.The data were analysed using t test and chi square test.Results Compared with non-steatosis group,the average age and body weight index of hepatic steatosis group were higher (t values were -3.31and -6.57,both P＜0.01).The percentage of moderate to severe hepatic inflammation in liver,obvious hepatic fibrosis and the strong positive HBsAg staining was lower (30.6％ vs 15.4％ ； 26.5％vs 12.8％； 23.1 ％ vs 6.7 ％； x2=9.63,8.92,15.76； all P＜0.01),and the percentage of strong positive HBcAg staining was also in downtrend.Compared with degree F1 and F2 of liver steatosis,the percentage of HBsAg and HBcAg strong positive staining in liver tissues of degree F3 and F4 was in downtrend.Conclusions Hepatic steatosis affected the expression of HBsAg and HBcAg in liver tissue of CHB patients.As hepatic steatosis appeared and became more severe,both expression of HBsAg and HBcAg and the degree of liver injury were in downtrend.
