CAJ | 학술논문

目的观察中性粒细胞明胶酶相关蛋白(NGAL)和基质金属蛋白酶10(MMP-10)在非小细胞肺癌(NSCLC)中的表达,探讨其与NSCLC浸润、转移的关系.方法采用免疫组织化学SP法检测70例非小细胞肺癌组织及30例癌旁肺组织标本中NGAL和MMP-10的表达,并分析它们的表达与相关临床参数的关系.结果 NSCLC组织中NGAL和MMP-10的表达分别为67.1%、70.0%,并与肿瘤直径、TNM分期、淋巴结转移明显相关(P<0.05),而与患者性别、年龄无关.NGAL和MMP-10的表达呈正相关(r=0.376,P=0.001).结论 NSCLC组织中NGAL和MMP-10表达明显增加.NGAL和MMP-10可能在NSCLC的发生、发展中起一定作用.
목적 관찰중성립세포명효매상관단백(NGAL)화기질금속단백매10(MMP-10)재비소세포폐암(NSCLC)중적표체,탐토기여NSCLC침윤、전이적관계.방법 채용면역조직화학SP법검측70례비소세포폐암조직급30례암방폐조직표본중NGAL화MMP-10적표체,병분석타문적표체여상관림상삼수적관계.결과 NSCLC조직중NGAL화MMP-10적표체분별위67.1%、70.0%,병여종류직경、TNM분기、림파결전이명현상관(P<0.05),이여환자성별、년령무관.NGAL화MMP-10적표체정정상관(r=0.376,P=0.001).결론 NSCLC조직중NGAL화MMP-10표체명현증가.NGAL화MMP-10가능재NSCLC적발생、발전중기일정작용.
Objective To observe the expression of neutrophil gelatinase associated lipocalin (NGAL) and matrix metalloproteinase 10(MMP10) in human non-small cell lung cancer(NSCLC) and to investigate their correlations with the infiltration and metastasis of NSCLC.Methods Immunohistochemistry method was applied to investigate the expression of NGAL and MMP-10 in specimens of 70 NSCLC tissues and 30 paracancerous tissues.The relationship between the expression of NGAL and MMP-10 in the NSCLC tissue and related clinical parameters were analyzed. Results The positive expression rates of NGAL and MMP-10 in NSCLC tissues were 67.1% and 70.0%,respectively. The expression of NGAL and MMP-10 in NSCLC tissues was correlated with the diameter of the mass, the pathological grading, the lymph node metastasis, but not correlated with sex, age and smoking. There was a positive correlation between NGAL and MMP-10 expression in lung squamous cell cancer tissues (r=0.376, P=0.001).Conclusions Higher expression of NGAL and MMP-10 may play an important role in carcinogenesis and development of NSCLC.