CAJ | 학술논문

目的分别滴用室温保存和冰箱冷藏后的苄达赖氨酸滴眼液，判断冷藏后的苄达赖氨酸滴眼液能否降低对眼的刺激。方法对照眼80例，滴用室温保存的本眼药液,试验眼80例，滴用冰箱冷藏后的苄达赖氨酸滴眼液,男女各半，按配对设计方案双盲法进行。结果滴眼后眼球刺激的出现率：对照眼为19.38%，受试眼为6.25%；出现B级和C级反应者：对照眼为31例，试验眼为10例；平均刺激等级：对照眼为1.21，试验眼为1.07。经秩和检验，两者有显著差异。出现局部刺激性记分改变：对照眼为1.57±1.50，试验眼为0.79±1.40, 两者有显著性差异;眼球出现刺激的开始反应时间及刺激反应的持续时间两者无显著差异。结论滴用冰箱冷藏后的滴眼液“一过性灼烧感”在刺激反应发生率和反应程度上，均比滴用在室温下保存的滴眼液有明显的改善（P<0.01）。
목적분별적용실온보존화빙상랭장후적변체뢰안산적안액，판단랭장후적변체뢰안산적안액능부강저대안적자격。방법대조안80례，적용실온보존적본안약액,시험안80례，적용빙상랭장후적변체뢰안산적안액,남녀각반，안배대설계방안쌍맹법진행。결과적안후안구자격적출현솔：대조안위19.38%，수시안위6.25%；출현B급화C급반응자：대조안위31례，시험안위10례；평균자격등급：대조안위1.21，시험안위1.07。경질화검험，량자유현저차이。출현국부자격성기분개변：대조안위1.57±1.50，시험안위0.79±1.40, 량자유현저성차이;안구출현자격적개시반응시간급자격반응적지속시간량자무현저차이。결론적용빙상랭장후적적안액“일과성작소감”재자격반응발생솔화반응정도상，균비적용재실온하보존적적안액유명현적개선（P<0.01）。
Objective　To evaluate whether the stimulation on eyes of bendazac lysine eyedrops could be reduced by cold storage.Methods　 Mate design scheme and double-blind clinical trial were performed. 160 healthy eyes was divided into two groups: the test group was given bendazac lysine eyedrops which was stored in refrigerator at 4℃ over night, and the control group was given it which was stored at room temperature.Results　ln the control group and the test group, the occuring rate of stimulation was 19.30% and 6.25%. The cases of B、C stimulation degrees were 31 and 10; the average stimulation degrees of each group were 1.21 and 1.07, the scoring change for eye stimulation were 1.57±1.50,0.79±1.40,all respectively. The statistical difference was significant (P＜0.05 or P＜0.01).Conclusion　The eye stimulation of bendazac lysine eyedrops can be reduced by cold storage.