天然产物研究与开发
天然產物研究與開髮
천연산물연구여개발
NATURAL PRODUCT RESEARCH AND DEVELOPMENT
2010年
2期
215-218,260
,共5页
花慧%冯磊%张小平%张莲芬%金坚
花慧%馮磊%張小平%張蓮芬%金堅
화혜%풍뢰%장소평%장련분%금견
合欢皮%血管生成%内皮细胞
閤歡皮%血管生成%內皮細胞
합환피%혈관생성%내피세포
Albizia julibrissin Durazz%angiogenesis%HMEC-1
本文采用体外细胞培养法和体内鸡胚尿囊绒膜模型、荷瘤模型检测合欢皮提取物抑制人微血管内皮细胞(HMEC-1)的增殖、迁移活性,观察合欢皮提取物的抑制血管生成情况.发现合欢皮提取物能显著抑制HMEC-1的增殖(IC_(50)为30μg/mL)和迁移,并且呈明显的剂量依赖性.在体内同时具有抑制鸡胚尿囊膜和肿瘤组织中血管生成的作用.
本文採用體外細胞培養法和體內鷄胚尿囊絨膜模型、荷瘤模型檢測閤歡皮提取物抑製人微血管內皮細胞(HMEC-1)的增殖、遷移活性,觀察閤歡皮提取物的抑製血管生成情況.髮現閤歡皮提取物能顯著抑製HMEC-1的增殖(IC_(50)為30μg/mL)和遷移,併且呈明顯的劑量依賴性.在體內同時具有抑製鷄胚尿囊膜和腫瘤組織中血管生成的作用.
본문채용체외세포배양법화체내계배뇨낭융막모형、하류모형검측합환피제취물억제인미혈관내피세포(HMEC-1)적증식、천이활성,관찰합환피제취물적억제혈관생성정황.발현합환피제취물능현저억제HMEC-1적증식(IC_(50)위30μg/mL)화천이,병차정명현적제량의뢰성.재체내동시구유억제계배뇨낭막화종류조직중혈관생성적작용.
The anti-angiogenenic effect of Albizia julibrissin extracts was examined by the model of HMEC-1 in vitro,chick chorioallantoic membrance and cancer in vivo.The results showed that Albizia julibrissin extracts could significantly inhibit the proliferation and migration of HMEC-1 in a dose-dependent manner(IC_(50)=30 μg/mL).It also inhibited the angiogenesis in chick chorioallantoic membrance and cancer in vivo.
