CAJ | 학술논문

近来许多研究证实未折叠蛋白反应(UPR)与2型糖尿病的发生密切相关,肌醇需求激酶1(IRE1)是一种定位于内质网膜的跨膜蛋白,参于UPR信号通路中信息的传递.IRE1信号通路是UPR主要的信号通路之一,IRE1活化后可通过激活IRE1-c-Jur氨基末端激酶(JNK)等信号通路,引起胰岛素抵抗,并最终导致胰岛β细胞凋亡,可见其在2型糖尿病发生中起重要作用.通过探讨IRE1信号通路在2型糖尿病发生、发展中的作用,将为治疗2型糖尿病提供新的途径.
근래허다연구증실미절첩단백반응(UPR)여2형당뇨병적발생밀절상관,기순수구격매1(IRE1)시일충정위우내질망막적과막단백,삼우UPR신호통로중신식적전체.IRE1신호통로시UPR주요적신호통로지일,IRE1활화후가통과격활IRE1-c-Jur안기말단격매(JNK)등신호통로,인기이도소저항,병최종도치이도β세포조망,가견기재2형당뇨병발생중기중요작용.통과탐토IRE1신호통로재2형당뇨병발생、발전중적작용,장위치료2형당뇨병제공신적도경.
Recently, many studies have demonstrated that the unfolded protein response (UPR) was closely related to the mechanism of type 2 diabetes. Inositol requiring enzyme 1 ( IRE1 ) is an endoplasmic reticulum-located transmembrane protein that participates in information transfer in the UPR signaling pathways.IRE1 signaling pathway is one of the important signalling pathways in the UPR. Activation of IRE1 signaling pathways may lead to the development of insulin resistance and islet β-cells apoptosis by activating IREl-c-Jun NH2-terminal kinase(JNK) signaling pathway and so on. Discussing the role of IRE1 in type 2 diabetes can provide a new approach of diabetes therapy.