CAJ | 학술논문

胰岛素抵抗(IR)在非酒精性脂肪性肝病(NAFLD)发病过程中起至关重要的作用.目前大量研究支持NAFLD“二次打击”学说,初次打击IR引起肝细胞单纯性脂肪变性,二次打击脂肪变的肝细胞发生成脂性转化,诱导炎性反应、氧化应激、内质网应激的发生,损伤肝细胞功能,加重IR,促进NAFLD发展.
이도소저항(IR)재비주정성지방성간병(NAFLD)발병과정중기지관중요적작용.목전대량연구지지NAFLD“이차타격”학설,초차타격IR인기간세포단순성지방변성,이차타격지방변적간세포발생성지성전화,유도염성반응、양화응격、내질망응격적발생,손상간세포공능,가중IR,촉진NAFLD발전.
Insulin resistance plays an important role in the development of nonalcoholic fatty liver disease (NAFLD).At present,numerous studies support the two “hits” theory of NAFLD.The first “hit” on insulin resistance leads to hepatocyte simplicity steatosis,and the second “hit” indicates that hepatocyte steatosis may result in the fat cells transformation,inflammatory reaction,oxidative stress,and endoplasmic reticulum stress,damaging the function of liver cells,aggravating insulin resistance,and promoting the development of NAFLD.