国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2009年
21期
1329-1332
,共4页
SPLUNC1%黏膜的免疫应答%呼吸道疾病
SPLUNC1%黏膜的免疫應答%呼吸道疾病
SPLUNC1%점막적면역응답%호흡도질병
SPLUNC1%Mucosal Immune Responses%Respiratory tract diseases
短的上腭、肺及鼻咽上皮克隆1(Short Palate Lung and Nasal epithelium CloRel,SPLUNC1)是最近发现的黏膜分泌蛋白上腭,肺及鼻咽上皮克隆基因(Palate Lung and Nasal epithelium Clone,PLUNC)家族的一员,特异表达于呼吸道,是呼吸道重要的天然防御分子.它不仅参与外来病原体特别是革兰阴性菌的清除和免疫应答、炎症的调节.而且也参与肿瘤的发生、发展,与多种人类呼吸道疾病有关.SPLUNC1可能成为鼻咽癌、非小细胞肺癌早期诊断及判断疗效、预后的一种非常有前景的标记物.
短的上腭、肺及鼻嚥上皮剋隆1(Short Palate Lung and Nasal epithelium CloRel,SPLUNC1)是最近髮現的黏膜分泌蛋白上腭,肺及鼻嚥上皮剋隆基因(Palate Lung and Nasal epithelium Clone,PLUNC)傢族的一員,特異錶達于呼吸道,是呼吸道重要的天然防禦分子.它不僅參與外來病原體特彆是革蘭陰性菌的清除和免疫應答、炎癥的調節.而且也參與腫瘤的髮生、髮展,與多種人類呼吸道疾病有關.SPLUNC1可能成為鼻嚥癌、非小細胞肺癌早期診斷及判斷療效、預後的一種非常有前景的標記物.
단적상악、폐급비인상피극륭1(Short Palate Lung and Nasal epithelium CloRel,SPLUNC1)시최근발현적점막분비단백상악,폐급비인상피극륭기인(Palate Lung and Nasal epithelium Clone,PLUNC)가족적일원,특이표체우호흡도,시호흡도중요적천연방어분자.타불부삼여외래병원체특별시혁란음성균적청제화면역응답、염증적조절.이차야삼여종류적발생、발전,여다충인류호흡도질병유관.SPLUNC1가능성위비인암、비소세포폐암조기진단급판단료효、예후적일충비상유전경적표기물.
Short Palate Lung and Nasal epithelium Clonel(SPI,UNC1),a member of Palate Lung Nasal Clone family,is an important innate immune defense molecule and specially expressed in the upper airway.It is involved in the regulation of immune,inflammation and clearance of pathogens,especially gramnegative bacterium,besides it possibly participates in the growth and development of tumor.SPLUNC1 may be a useful marker for the diagnosis and prognosis in non-small cell lung cancer and nasopharyngeal carcinoma.
