CAJ | 학술논문

呼吸道病毒感染是小年龄患儿喘息最为常见的诱因,也是慢性哮喘患儿出现急性加重的主要诱发因素.关于呼吸道病毒感染引发气道炎症反应的机制尚不完全明确,目前有研究提出用表观遗传学机制来解释病毒感染与哮喘的关系.该文就婴幼儿期呼吸道病毒感染在儿童时期哮喘发生发展中作用的研究进展作一综述.
호흡도병독감염시소년령환인천식최위상견적유인,야시만성효천환인출현급성가중적주요유발인소.관우호흡도병독감염인발기도염증반응적궤제상불완전명학,목전유연구제출용표관유전학궤제래해석병독감염여효천적관계.해문취영유인기호흡도병독감염재인동시기효천발생발전중작용적연구진전작일종술.
Respiratory viral infections are the most common cause of infantile wheezing, as well as one of the major inducents of acute exacebarbations of chronic childhood asthma. Recent studies focus on the mechanism of virus-induced airway inflammatory response which is still not completely clear. Many new pathophysiologic mechanisms such as epigenetics are advanced to explain the association between viral respiratory infections and asthma attack. In the present reports, recent data on the role of early-life viral infections in the development and progression of childhood asthma are reviewed.