中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2008年
4期
214-218
,共5页
李华信%高春芳%马成龙%孙良起%李晓冰%王平%李顺飞%高延芳%王晓静%王晓川
李華信%高春芳%馬成龍%孫良起%李曉冰%王平%李順飛%高延芳%王曉靜%王曉川
리화신%고춘방%마성룡%손량기%리효빙%왕평%리순비%고연방%왕효정%왕효천
女性%解脲支原体%支原体,人型%泌尿生殖系统%抗药性
女性%解脲支原體%支原體,人型%泌尿生殖繫統%抗藥性
녀성%해뇨지원체%지원체,인형%비뇨생식계통%항약성
Female%Ureaplasma urealyticum%Mycoplasma hominis%Urogenital system%Drug resistance
目的 研究女性泌尿生殖系统支原体感染状况及耐药性变迁,以指导临床合理应用抗菌药物.方法 采用病原培养法和荧光定量PCR法对2007年530例女性泌尿生殖道样本进行解脲支原体(UU)和人型支原体(MH)检测,同时进行体外药物敏感性试验,并与2000年的检测结果进行比较分析.结果 2000年共检出99例支原体感染,其中UU 65例,MH 15例,UU+MH 19例;2007年共检出344例支原体感染,其中UU 236例,MH 47例,UU+MH 61例.≤20岁年龄组支原体感染率由2000年的5.0%上升到2007年的12.8%,差异有统计学意义(χ2=4.682,P<0.05);21～30岁年龄组支原体感染率最高,两个年份分别为46.2%和50.5%.2000年和2007年,四环素和红霉素的耐药率均在80%以上;与2000年相比,2007年女性泌尿生殖系统支原体对左氧氟沙星、阿奇霉素和氧氟沙星的耐药率明显升高,差异有统计学意义(P均<0.05),而对强力霉素(DOX)、米诺环素(MIN)和交沙霉素(JOS)的耐药率最低且变化不显著.结论 女性泌尿生殖系统炎性反应以UU感染为主.女性泌尿生殖系统支原体感染有低龄化趋势,应引起社会各界的广泛关注.UU和MH对大部分大环内酯类和喹诺酮类药物的耐药性较高,临床上应尽量根据药物敏感性试验结果选择抗菌药物.DOX、MIN和JOS耐药率低且变化小,可在临床经验用药中作为首选药物.
目的 研究女性泌尿生殖繫統支原體感染狀況及耐藥性變遷,以指導臨床閤理應用抗菌藥物.方法 採用病原培養法和熒光定量PCR法對2007年530例女性泌尿生殖道樣本進行解脲支原體(UU)和人型支原體(MH)檢測,同時進行體外藥物敏感性試驗,併與2000年的檢測結果進行比較分析.結果 2000年共檢齣99例支原體感染,其中UU 65例,MH 15例,UU+MH 19例;2007年共檢齣344例支原體感染,其中UU 236例,MH 47例,UU+MH 61例.≤20歲年齡組支原體感染率由2000年的5.0%上升到2007年的12.8%,差異有統計學意義(χ2=4.682,P<0.05);21～30歲年齡組支原體感染率最高,兩箇年份分彆為46.2%和50.5%.2000年和2007年,四環素和紅黴素的耐藥率均在80%以上;與2000年相比,2007年女性泌尿生殖繫統支原體對左氧氟沙星、阿奇黴素和氧氟沙星的耐藥率明顯升高,差異有統計學意義(P均<0.05),而對彊力黴素(DOX)、米諾環素(MIN)和交沙黴素(JOS)的耐藥率最低且變化不顯著.結論 女性泌尿生殖繫統炎性反應以UU感染為主.女性泌尿生殖繫統支原體感染有低齡化趨勢,應引起社會各界的廣汎關註.UU和MH對大部分大環內酯類和喹諾酮類藥物的耐藥性較高,臨床上應儘量根據藥物敏感性試驗結果選擇抗菌藥物.DOX、MIN和JOS耐藥率低且變化小,可在臨床經驗用藥中作為首選藥物.
목적 연구녀성비뇨생식계통지원체감염상황급내약성변천,이지도림상합리응용항균약물.방법 채용병원배양법화형광정량PCR법대2007년530례녀성비뇨생식도양본진행해뇨지원체(UU)화인형지원체(MH)검측,동시진행체외약물민감성시험,병여2000년적검측결과진행비교분석.결과 2000년공검출99례지원체감염,기중UU 65례,MH 15례,UU+MH 19례;2007년공검출344례지원체감염,기중UU 236례,MH 47례,UU+MH 61례.≤20세년령조지원체감염솔유2000년적5.0%상승도2007년적12.8%,차이유통계학의의(χ2=4.682,P<0.05);21～30세년령조지원체감염솔최고,량개년빈분별위46.2%화50.5%.2000년화2007년,사배소화홍매소적내약솔균재80%이상;여2000년상비,2007년녀성비뇨생식계통지원체대좌양불사성、아기매소화양불사성적내약솔명현승고,차이유통계학의의(P균<0.05),이대강력매소(DOX)、미낙배소(MIN)화교사매소(JOS)적내약솔최저차변화불현저.결론 녀성비뇨생식계통염성반응이UU감염위주.녀성비뇨생식계통지원체감염유저령화추세,응인기사회각계적엄범관주.UU화MH대대부분대배내지류화규낙동류약물적내약성교고,림상상응진량근거약물민감성시험결과선택항균약물.DOX、MIN화JOS내약솔저차변화소,가재림상경험용약중작위수선약물.
Objective To investigate the infection of Mycoplasma in female urogenital system and the evolution of drug resistance. Methods Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) infections were examined by pathogen culture and fluorescence quantitative PCR in urogenital samples from 530 female patients in 2007, and drug sensitivity tests were performed in vitro. The results were compared with those in 2000. Results In 2000, there were 99 patients with Mycoplasma infections, in which 65 were of UU infections, 15 were of MH infections and 19 were of UU + MH infections. In 2007, there were 344 patients with Mycoplasma infections, in which 236 were of UU infections, 47 were of MH infections and 61 were of UU + MH infections. Patients aged 21～30 had the highest Mycoplasma infection rates both in 2000 (46.2%) and 2007 ( 50.5% ) ; while Mycoplasma infection rate in patients aged under 20 rose from 5.1% in 2000 to 12.8% in 2007 (χ2 = 4.682, P < 0.05). Both in 2000 and 2007, pathogens presented the highest drug resistance rates to tetracycline (TET) and erythromycin ( ERY ) which were all bore 80%. Compared with 2000, drug resistance rates to levofloxacin (LEV), azitromvcin (AZI) and ofloxacin (OFL) rose in 2007, and the differences were of statistical significance (P <0.05), while drug resistance rates to dmoxycycline (DOX), minocyclin (MIN) and josamycin (JOS) were still in the low level. Conclusions UU is the primary pathogen of infection in female urogenital system, and there is a tendency of Mycoplasma infection in younger age women. DOX, MIN and JOS can be the preferred medicines for Mycoplasma infections.
