CAJ | 학술논문

多氯联苯(PCBs)是一类在环境中广泛存在的持久性有机污染物,对生物体具有蓄积毒性.研究表明PCBs表现出的分子遗传毒性能够引起神经系统、内分泌系统、生殖系统等相关基因表达的显著调节.低等动物、模型动物及啮齿类动物被大量应用于研究PCBs对分子和细胞功能相关基因及生理发育功能相关基因的影响.目前,对于PCBs人群流行病学的研究多集中于部分疾病易感基因,如细胞色素P450、癌基因等.对PCBs分子遗传毒性的探讨对于阐释其遗传毒性机制具有深刻的意义,此文就PCBs的分子遗传毒性及流行病学研究进展作一综述.
다록련분(PCBs)시일류재배경중엄범존재적지구성유궤오염물,대생물체구유축적독성.연구표명PCBs표현출적분자유전독성능구인기신경계통、내분비계통、생식계통등상관기인표체적현저조절.저등동물、모형동물급교치류동물피대량응용우연구PCBs대분자화세포공능상관기인급생리발육공능상관기인적영향.목전,대우PCBs인군류행병학적연구다집중우부분질병역감기인,여세포색소P450、암기인등.대PCBs분자유전독성적탐토대우천석기유전독성궤제구유심각적의의,차문취PCBs적분자유전독성급류행병학연구진전작일종술.
Polychlorinated biphenyls (PCBs) is a kind of extensively existed persistent organic pollutants (POPs)in the environment,which can cause accumulative poisonous effects to organism.Many studies indicated that PCBs have molecular genetic toxicity,which can cause significant regulation of related genes on nervous system,endocrine system and genital system.Lower animals,model animals and rodent animals have been widely used to study the related genes of molecular,cellular,physiological and developmental function.The epidemiologic studies of PCBs mainly focused on partial disease susceptible genes such as cytochrome P450 gene and oncogene.It' s deeply meaningful and worth further study to investigate the molecular genetic toxicity of PCBs and illustrate its mechanism,the research advances of the molecular genetic toxicity and epidemiologic study of PCBs are reviewed.