中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2012年
1期
16-19
,共4页
李艳丽%杨甫德%谭云龙%朱凤艳%王宁%陈松%王志仁%周东丰
李豔麗%楊甫德%譚雲龍%硃鳳豔%王寧%陳鬆%王誌仁%週東豐
리염려%양보덕%담운룡%주봉염%왕저%진송%왕지인%주동봉
抗精神病药%运动障碍,药物性%血浆%抗氧化剂%白蛋白类%胆红素%尿酸
抗精神病藥%運動障礙,藥物性%血漿%抗氧化劑%白蛋白類%膽紅素%尿痠
항정신병약%운동장애,약물성%혈장%항양화제%백단백류%담홍소%뇨산
Antipsychotic agents%Dyskinesia,drug-induced%Plasma%Antioxidant%Albumins%Bilirubin%Uric acid
目的 探讨抗精神病药所致迟发性运动障碍(TD)患者血浆非酶抗氧化物浓度变化与TD的关系.方法 分别运用阳性和阴性症状量表(PANSS)和异常不自主运动量表(AIMS)评定精神症状和TD严重程度；使用全自动生化仪测定TD组(60例)、非TD组(60例)和对照组(45名)血浆白蛋白(Alb)、胆红素(Bil)、尿酸(UA)浓度,采用方差分析比较3组间上述指标的差异；采用单因素非条件Logistic回归分析各项生化指标与TD患者临床特征间的关系.结果 与对照组[(46.8±3.4) g/L和(12.7 ±3.3) μmol/L]比较,TD组[(40.2±2.5) g/L、(9.2±2.1)μmol/L]和非TD组[(41.2±2.3) g/L、(10.2 ±3.1)μmol/L] Alb和Bil明显降低,差异有统计学意义(P均＜0.001)；TD组Alb浓度低于非TD组(P =0.033),Bil浓度差异趋于显著水平(P =0.052),UA浓度差异无统计学意义；TD组AIMS总分与Bil(r=-0.373,P=0.008)、阴性症状分(r=-0.262,P=0.044)显著相关.结论 非酶抗氧化物可能在TD的病生理机制中起一定作用.
目的 探討抗精神病藥所緻遲髮性運動障礙(TD)患者血漿非酶抗氧化物濃度變化與TD的關繫.方法 分彆運用暘性和陰性癥狀量錶(PANSS)和異常不自主運動量錶(AIMS)評定精神癥狀和TD嚴重程度；使用全自動生化儀測定TD組(60例)、非TD組(60例)和對照組(45名)血漿白蛋白(Alb)、膽紅素(Bil)、尿痠(UA)濃度,採用方差分析比較3組間上述指標的差異；採用單因素非條件Logistic迴歸分析各項生化指標與TD患者臨床特徵間的關繫.結果 與對照組[(46.8±3.4) g/L和(12.7 ±3.3) μmol/L]比較,TD組[(40.2±2.5) g/L、(9.2±2.1)μmol/L]和非TD組[(41.2±2.3) g/L、(10.2 ±3.1)μmol/L] Alb和Bil明顯降低,差異有統計學意義(P均＜0.001)；TD組Alb濃度低于非TD組(P =0.033),Bil濃度差異趨于顯著水平(P =0.052),UA濃度差異無統計學意義；TD組AIMS總分與Bil(r=-0.373,P=0.008)、陰性癥狀分(r=-0.262,P=0.044)顯著相關.結論 非酶抗氧化物可能在TD的病生理機製中起一定作用.
목적 탐토항정신병약소치지발성운동장애(TD)환자혈장비매항양화물농도변화여TD적관계.방법 분별운용양성화음성증상량표(PANSS)화이상불자주운동량표(AIMS)평정정신증상화TD엄중정도；사용전자동생화의측정TD조(60례)、비TD조(60례)화대조조(45명)혈장백단백(Alb)、담홍소(Bil)、뇨산(UA)농도,채용방차분석비교3조간상술지표적차이；채용단인소비조건Logistic회귀분석각항생화지표여TD환자림상특정간적관계.결과 여대조조[(46.8±3.4) g/L화(12.7 ±3.3) μmol/L]비교,TD조[(40.2±2.5) g/L、(9.2±2.1)μmol/L]화비TD조[(41.2±2.3) g/L、(10.2 ±3.1)μmol/L] Alb화Bil명현강저,차이유통계학의의(P균＜0.001)；TD조Alb농도저우비TD조(P =0.033),Bil농도차이추우현저수평(P =0.052),UA농도차이무통계학의의；TD조AIMS총분여Bil(r=-0.373,P=0.008)、음성증상분(r=-0.262,P=0.044)현저상관.결론 비매항양화물가능재TD적병생리궤제중기일정작용.
Objective To inv.estigate the plasma non-enzyme antioxidants levels in chronic schizophrenic patients with tardive dyskinesia ( TD).Methods The plasma levels of albumin ( Alb),bilirubin (Bil) and uric acid (UA) in schizophrenic patients with TD (TD group,n =60) and without TD ( non-TD group,n =60) and healthy volunteers ( control group,n =45 ) were assayed by using full automatic biochemical analysor. The plasma antioxidants levels were compared among three groups by one-way ANOVA.Psychopathological symptoms and severities of TD were assessed by using the Positive and Negative Symptom Scale(PANSS) and Abnormal Involuntary Movement Scale (AIMS) respectively,the relationships of the plasma antioxidants levels and the clinical traits of TD were analyzed.Results Plasma Alb and Bil in control group [ (46.8 ± 3.4) g/L,( 12.7 ± 3.3 ) μmol/L] were significantly higher than those in TD [ (40.2 ±2.5) g/L,(9.2 ± 2.1 ) μ mol/L] and non-TD [ (41.2 ± 2.3 ) g/L,( 10.2 ± 3.1 ) μmol/L]groups (all P ＜ 0.001 ),but there were no significant differences on plasma UA concentrations among the three groups ( F =1.42,P =0.234).There was significant difference on the Alb concentrations between the TD and non-TD group ( P =0.033 ),and trend significant difference on Bil levels ( P =0.052 ).In TD group,the total score of AIMS were negatively related with Bil concentrations (r =-0.373,P =0.008) and negative sub-score of PANSS (r =- 0.262,P =0.044).Conclusions The non-enzyme antioxidants might be involved in the pathophysiology of TD.
