CAJ | 학술논문

通过高糖高脂饮食诱导建立SD大鼠代谢综合征(MS)模型.茶多酚干预10周后大鼠空腹血糖、甘油三酯、胆固醇、低密度脂蛋白胆固醇、游离脂肪酸水平均较MS组明显下降(均P＜0.05),茶多酚组胰腺组织肿瘤坏死因子α、干扰素、诱导型一氧化氮合酶的mRNA和蛋白表达较MS组明显下降(均P＜0.05),白细胞介素1β蛋白表达也明显降低(P＜0.05).电镜观察茶多酚组大鼠胰岛β细胞的分泌颗粒较MS组增多,细胞器结构破坏减轻.提示茶多酚可通过抑制炎性细胞因子的产生,保护胰岛β细胞免受损伤.
통과고당고지음식유도건립SD대서대사종합정(MS)모형.다다분간예10주후대서공복혈당、감유삼지、담고순、저밀도지단백담고순、유리지방산수평균교MS조명현하강(균P＜0.05),다다분조이선조직종류배사인자α、간우소、유도형일양화담합매적mRNA화단백표체교MS조명현하강(균P＜0.05),백세포개소1β단백표체야명현강저(P＜0.05).전경관찰다다분조대서이도β세포적분비과립교MS조증다,세포기결구파배감경.제시다다분가통과억제염성세포인자적산생,보호이도β세포면수손상.
A rat model of metabolic syndrome was induced by high glucose plus high fat diet and treated by tea polyphenols for 10 weeks.The results showed that the levels of fasting blood glucose,triglyceride,cholesterol,low-density lipoprotein cholesterol,and free fatty acid in tea polyphenols treatment group were significantly lower than those in control group(all P＜0.05),along with decreased TNF-α,IFN-γ,iNOS mRNA and protein expressions,and IL-1β protein expression in pancreatictissue (all P＜0.05).Under electron microscope,more secretory granules in islet beta cells and impoveddisorganization of cellular organ were shown in tea polyphenols treatment group compared with metabolic syndrome group.The results suggest that tea polyphenols are able to protect islet β cells against oxidative damage via inhibiting the production of inflammatory cytokines.