中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2011年
6期
395-399
,共5页
汪晓楠%万新华%王琳%杨英麦
汪曉楠%萬新華%王琳%楊英麥
왕효남%만신화%왕림%양영맥
眼睑痉挛%危险因素%问卷调查
眼瞼痙攣%危險因素%問捲調查
안검경련%위험인소%문권조사
Blepharospasm%Risk factors%Questionnaires
目的 探讨良性特发性眼睑痉挛(benign essential blepharospasm,BEB)发病的危险因素以及各因素的作用强度.方法 病例组为2009年4月至2010年3月在中国医学科学院北京协和医院神经内科门诊就诊的BEB患者100例,可合并相邻部位的肌张力障碍.对照组来自同期神经科门诊就诊的偏侧面肌痉挛(hemifacial spasm,HFS)患者100例以及健康对照40名,男女比例与病例组匹配,无锥体外系及其他神经系统疾病.对所有研究对象进行问卷调查,包括一般情况、社会行为因素、环境因素、精神因素、遗传因素、既往病史.数据录入SPSS 11.0软件进行Logistic回归分析.结果 多因素回归分析显示,眼病(OR=5.818,95% CI 2.510～13.486)、焦虑(OR=3.433,95% CI 1.548～7.610)、抑郁(OR=2.894,95% CI 1.091～7.681)与BEB呈显著正相关,饮用咖啡(OR=0.251,95% CI 0.080～0.784)与BEB呈显著负相关(均P＜0.05).结论 眼疾、焦虑、抑郁可能是BEB发病的独立危险因素;一过性意识障碍的头面部外伤史与BEB有一定的相关性;咖啡饮用史可能是BEB的保护因素.局部损伤及精神因素作为BEB发病的危险因素可能比遗传因素更重要.
目的 探討良性特髮性眼瞼痙攣(benign essential blepharospasm,BEB)髮病的危險因素以及各因素的作用彊度.方法 病例組為2009年4月至2010年3月在中國醫學科學院北京協和醫院神經內科門診就診的BEB患者100例,可閤併相鄰部位的肌張力障礙.對照組來自同期神經科門診就診的偏側麵肌痙攣(hemifacial spasm,HFS)患者100例以及健康對照40名,男女比例與病例組匹配,無錐體外繫及其他神經繫統疾病.對所有研究對象進行問捲調查,包括一般情況、社會行為因素、環境因素、精神因素、遺傳因素、既往病史.數據錄入SPSS 11.0軟件進行Logistic迴歸分析.結果 多因素迴歸分析顯示,眼病(OR=5.818,95% CI 2.510～13.486)、焦慮(OR=3.433,95% CI 1.548～7.610)、抑鬱(OR=2.894,95% CI 1.091～7.681)與BEB呈顯著正相關,飲用咖啡(OR=0.251,95% CI 0.080～0.784)與BEB呈顯著負相關(均P＜0.05).結論 眼疾、焦慮、抑鬱可能是BEB髮病的獨立危險因素;一過性意識障礙的頭麵部外傷史與BEB有一定的相關性;咖啡飲用史可能是BEB的保護因素.跼部損傷及精神因素作為BEB髮病的危險因素可能比遺傳因素更重要.
목적 탐토량성특발성안검경련(benign essential blepharospasm,BEB)발병적위험인소이급각인소적작용강도.방법 병례조위2009년4월지2010년3월재중국의학과학원북경협화의원신경내과문진취진적BEB환자100례,가합병상린부위적기장력장애.대조조래자동기신경과문진취진적편측면기경련(hemifacial spasm,HFS)환자100례이급건강대조40명,남녀비례여병례조필배,무추체외계급기타신경계통질병.대소유연구대상진행문권조사,포괄일반정황、사회행위인소、배경인소、정신인소、유전인소、기왕병사.수거록입SPSS 11.0연건진행Logistic회귀분석.결과 다인소회귀분석현시,안병(OR=5.818,95% CI 2.510～13.486)、초필(OR=3.433,95% CI 1.548～7.610)、억욱(OR=2.894,95% CI 1.091～7.681)여BEB정현저정상관,음용가배(OR=0.251,95% CI 0.080～0.784)여BEB정현저부상관(균P＜0.05).결론 안질、초필、억욱가능시BEB발병적독립위험인소;일과성의식장애적두면부외상사여BEB유일정적상관성;가배음용사가능시BEB적보호인소.국부손상급정신인소작위BEB발병적위험인소가능비유전인소경중요.
Objective To explore the risk factors of benign essential blepharospasm( BEB) and each factor' s intensity.Methods Totally 100 patients with BEB including Meige and cranial-cervical without other neurological abnormalities were recuited from the outpatient clinic of Department of Neurology, Peking Union Medical College Hospital from April 2009 to March 2010 as case group.At the same time, 100 outpatients diagnosed with idiopathic hemifacial spasm ( HFS) and 40 healthy controls without extrapyramidal diseases or other neurological diseases were recuited from the same outpatient clinic.All the cases and controls were investigated by questionnaires about general conditions, social behavioral factors, environmental factors, phychiatrical factors, genetic factors, previous diseases.The data was analysed by Logistic regression model with the statistical software SPSS 11.0.Results Multivariate analysis indicated that eye disease (OR = 5.818, 95% CI 2.510-13.486), anxiety (OR=3.433, 95% CI 1.548-7.610) and depression (OR =2.894, 95% CI 1.091-7.681) were positively related with BEB, whereas coffee drinking (OR = 0.251, 95% CI 0.080-0.784) had a negative relationship with BEB ( all P ＜ 0.05 ).Conclusions The risk factors of BEB are eye diseases, anxiety and depression.Coffee drinking is protective for BEB.The results suggest that local injury and phychiatrical factors may be more important than genetic factor in the aetiology of BEB.
