中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
11期
26-27
,共2页
心包置管%肺癌%心包积液
心包置管%肺癌%心包積液
심포치관%폐암%심포적액
Catheter implanted in pericardium%Lung cancer%Pericardial effusion
目的 探讨长期心包内置管治疗肺癌伴心包转移的近期疗效和对患者生存时间的影响以及安全性.方法 将入选106例患者随机分为A、B两组.A组53例为长期置管组,置管时间为8周;B组53例为短期置管组,置管时间＜4周.两组患者均接受相同的治疗方案,分别观察近期疗效、半数生存时间、两个月内的复发率及置管并发症.结果 A,B两组近期完全缓解率(53.33%vs 37.5%,X2=4.17,P＜0.05)和总有效率(91.67%vs 76.59%,X2=3.87,P＜0.05),均有统计学意义.拔管后两个月内的复发率A、B两组分别为20.83%和39.58%(X2=4.00,P＜0.05),1年内的存活率分别为43.75%和20.83%(X2=5.76,P＜0.05),两者比较均有显著性差异.半数生存期两组分别为8个月和4个月.A,B两组生存率分析有统计学意义(P＜0.05).两组患者均未发现化脓感染、窦道形成、心包感染及严重粘连等并发症.结论 长期心包置管治疗疗效可靠,安全性高,尤其对心包内有癌细胞种植的患者,可明显延长其生存时间.
目的 探討長期心包內置管治療肺癌伴心包轉移的近期療效和對患者生存時間的影響以及安全性.方法 將入選106例患者隨機分為A、B兩組.A組53例為長期置管組,置管時間為8週;B組53例為短期置管組,置管時間＜4週.兩組患者均接受相同的治療方案,分彆觀察近期療效、半數生存時間、兩箇月內的複髮率及置管併髮癥.結果 A,B兩組近期完全緩解率(53.33%vs 37.5%,X2=4.17,P＜0.05)和總有效率(91.67%vs 76.59%,X2=3.87,P＜0.05),均有統計學意義.拔管後兩箇月內的複髮率A、B兩組分彆為20.83%和39.58%(X2=4.00,P＜0.05),1年內的存活率分彆為43.75%和20.83%(X2=5.76,P＜0.05),兩者比較均有顯著性差異.半數生存期兩組分彆為8箇月和4箇月.A,B兩組生存率分析有統計學意義(P＜0.05).兩組患者均未髮現化膿感染、竇道形成、心包感染及嚴重粘連等併髮癥.結論 長期心包置管治療療效可靠,安全性高,尤其對心包內有癌細胞種植的患者,可明顯延長其生存時間.
목적 탐토장기심포내치관치료폐암반심포전이적근기료효화대환자생존시간적영향이급안전성.방법 장입선106례환자수궤분위A、B량조.A조53례위장기치관조,치관시간위8주;B조53례위단기치관조,치관시간＜4주.량조환자균접수상동적치료방안,분별관찰근기료효、반수생존시간、량개월내적복발솔급치관병발증.결과 A,B량조근기완전완해솔(53.33%vs 37.5%,X2=4.17,P＜0.05)화총유효솔(91.67%vs 76.59%,X2=3.87,P＜0.05),균유통계학의의.발관후량개월내적복발솔A、B량조분별위20.83%화39.58%(X2=4.00,P＜0.05),1년내적존활솔분별위43.75%화20.83%(X2=5.76,P＜0.05),량자비교균유현저성차이.반수생존기량조분별위8개월화4개월.A,B량조생존솔분석유통계학의의(P＜0.05).량조환자균미발현화농감염、두도형성、심포감염급엄중점련등병발증.결론 장기심포치관치료료효가고,안전성고,우기대심포내유암세포충식적환자,가명현연장기생존시간.
Objective The present study was undertaken to investigate the effects of long term extraction from pericardium on the life of the patients,and to evaluate the early effects and safety of long-term implanted catheter in pericardium on them with lung cancer and pericardial transmission.Methods 96 coses enrolled were randomly devided into two groups(group A and group B),the period of implanted catheter was eight weeks in group A and less than four weeks in group B.The treatment protocal of the two groups was the same,then to observe the outcome,survival time of patients the recurrence rate of pericardial effusion,the complications relevant to the catheter.Results The early complete relief rate(CRR)of two groups(A,B)was of statistic significance(53.33%vs 37.5%,X2=4.17,P＜0.05),the total effective rate of two groups had the statistic differences(91.67%vs 77.08%,X2=3.87,P＜0.05).The recurrence rate of two groups within two months was 20.83%and 39.58%(X2=4.00,P＜0.05),the survival rate of group A and group B within one year was 43.75%and 20.83%(X2=5.76,P＜0.05).The median period of two groups was 8 months and4 months..The survival rate of two group was of statistic significance(P＜0.05)within one year.There were not pyogenic infection,fistula formation,penicarditis severe pericardiosymphysis and myocardial injury between two groups.Conclusion The long-term implanted catheter treatment is an effective and safe way to lung cancer patients with pericardial transmission,which may prolong the survival time of them.
