CAJ | 학술논문

目的观察呼吸门控与非门控PET/CT显像测定肺部结节SUV的差异,探讨不同呼吸时相SUV变化趋势.方法 2010年5月至2011年3月进行PET/CT显像、发现有多个肺部结节并同意进行呼吸门控显像者共19例,最终14例共37个结节纳入该研究,其中男6例,女8例,年龄29 ～ 80(63.7±7.1)岁.对所有患者进行常规和呼吸门控PET/CT采集.经过后台处理得到呼吸时相相匹配的1个呼吸周期内6个时相的PET/CT融合图像.测得SUV,每个肺部结节的每个指标均进行非门控与门控显像6个时相共7次测量.采用SPSS 13.0软件对数据行t检验、秩和检验和相关分析.结果 37个肺部结节呼吸门控显像的SUVmax和SUVmean分别为13.69±6.70和8.56±4.11,明显高于非门控PET/CT的12.76±6.74及7.66±4.00(t =3.475和Z=-3.661,P均＜0.001)；但2种显像技术SUVmax与SUVmean相关性好(r=0.971和0.969,P均＜0.05)；在门控显像中,6个时相不同时相间SUV以时相1即吸气末最高,而时相4(呼气末吸气初)最低.37个结节中4个结节常规显像SUV＜ 2.5(定义为轻度摄取),其中有1个结节SUVmax由非门控显像的2.13升至门控显像的2.52.结论采用呼吸门控PET/CT显像所得到的肺部结节SUVmax和SUVmean比非门控常规采集高,但两者相关性好；SUV不同时相间以吸气末最高.对轻度摄取FDG的结节,经呼吸门控PET/CT其SUV有所提高,有可能影响临床诊断.
목적 관찰호흡문공여비문공PET/CT현상측정폐부결절SUV적차이,탐토불동호흡시상SUV변화추세.방법 2010년5월지2011년3월진행PET/CT현상、발현유다개폐부결절병동의진행호흡문공현상자공19례,최종14례공37개결절납입해연구,기중남6례,녀8례,년령29 ～ 80(63.7±7.1)세.대소유환자진행상규화호흡문공PET/CT채집.경과후태처리득도호흡시상상필배적1개호흡주기내6개시상적PET/CT융합도상.측득SUV,매개폐부결절적매개지표균진행비문공여문공현상6개시상공7차측량.채용SPSS 13.0연건대수거행t검험、질화검험화상관분석.결과 37개폐부결절호흡문공현상적SUVmax화SUVmean분별위13.69±6.70화8.56±4.11,명현고우비문공PET/CT적12.76±6.74급7.66±4.00(t =3.475화Z=-3.661,P균＜0.001)；단2충현상기술SUVmax여SUVmean상관성호(r=0.971화0.969,P균＜0.05)；재문공현상중,6개시상불동시상간SUV이시상1즉흡기말최고,이시상4(호기말흡기초)최저.37개결절중4개결절상규현상SUV＜ 2.5(정의위경도섭취),기중유1개결절SUVmax유비문공현상적2.13승지문공현상적2.52.결론 채용호흡문공PET/CT현상소득도적폐부결절SUVmax화SUVmean비비문공상규채집고,단량자상관성호；SUV불동시상간이흡기말최고.대경도섭취FDG적결절,경호흡문공PET/CT기SUV유소제고,유가능영향림상진단.
Objective To analyze the difference of SUV between respiratory gated (RG) and nongated PET/CT scans,and to investigate the trend of SUV change in different respiratory phases.Methods Fourteen patients (6 male,8 female,age range:29 to 80 years,average age:63.7 ± 7.1 years) with pulmonary nodules who had undergone both RG and non-gated PET/CT between May 2010 to March 2011 were enrolled in the study.A total of 37 pulmonary nodules were identified.Both PET and CT gated data were divided into 6 phases.PET images were matched with CT at different respiratory phases.Each nodule was measured 7 times including gated data of 6 phases and non-gated data.The t-test,rank-sum test and Spearman correlation analysis were used.Results The SUVmax and SUVmean of RG PET/CT ( 13.69 ± 6.70 and 8.56 ±4.11,respectively) were higher than those of non-gated PET/CT ( 12.76 ± 6.74 and 7.66 ±4.00,respectively) (t =3.475,Z =- 3.661,both P ＜ 0.001 ).The two sets were correlated with each other (r =0.971 and 0.969,both P ＜ 0.05).SUVmax was the highest at phase 1 ( end of expiration) and lowest at phase 4 (end of inspiration).In non-gated scans,there were 4 nodules with SUVmax ＜ 2.5,including 1 nodule with a higher SUV of 2.52 in the RG scan than SUV of 2.13 in the non-gated scan.Conclusions SUV of lung nodules in RG scans is higher than that in non-gated scans.The highest SUVmax could be obtained at the end of expiration.RG scans might improve the detection of lung nodules with low-grade FDG uptake.