CAJ | 학술논문

巨噬细胞是结核分枝杆菌在机体内的主要宿主细胞.细胞介导的免疫反应是机体抗结核分枝杆菌的主要免疫保护机制,巨噬细胞可通过吞噬、溶酶体融合,提呈结核分枝杆菌抗原,产生多种细胞因子、反应氧中间产物和反应氮中间产物,以及细胞凋亡等多种途径来杀灭结核分枝杆菌;同时,结核分枝杆菌也可采取各种方式来逃逸巨噬细胞的免疫作用.本文就巨噬细胞与结核分枝杆菌的免疫反应的研究进展作一综述.
거서세포시결핵분지간균재궤체내적주요숙주세포.세포개도적면역반응시궤체항결핵분지간균적주요면역보호궤제,거서세포가통과탄서、용매체융합,제정결핵분지간균항원,산생다충세포인자、반응양중간산물화반응담중간산물,이급세포조망등다충도경래살멸결핵분지간균;동시,결핵분지간균야가채취각충방식래도일거서세포적면역작용.본문취거서세포여결핵분지간균적면역반응적연구진전작일종술.
Macrophage is the main host cell of Mycobacterium tuberculosis in the body. Cellmediated immune response is the main immune protection mechanism in the anti-Mycobacterium tuberculosis. Macrophage kills Mycobacterium tuberculosis through phagocytosis, lysosome fusion,presenting antigens of Mycobacterium tuberculosis, producing a variety of cytokines, reactive oxygen intermediates and reactive nitrogen intermediates, apoptosis and many other ways. Meanwhile,Mycobacterium tuberculosis can take a variety of ways to escape the immune function of macrophages.This article reviews the research progress on immune response of macrophage and Mycobacterium tuberculosis.