CAJ | 학술논문

γ-氨基丁酸A型-苯二氮革(GABAA-BZ)受体广泛分布于中枢神经系统,是嵌于神经细胞膜上的异质性多肽五聚体,不同的亚单位组合发挥不同的神经抑制性药理作用,如镇静催眠、抗惊厥、抗焦虑等.PET可用于活体内受体结合的研究.GABAA-BZ受体PET显像剂分为拮抗剂、激动剂、反向激动剂3类,其中以拮抗剂显像剂11C-氟马西尼最为成熟,在癫癎、焦虑症、抑郁症、植物状态、成瘾等神经精神疾病中广泛应用.
γ-안기정산A형-분이담혁(GABAA-BZ)수체엄범분포우중추신경계통,시감우신경세포막상적이질성다태오취체,불동적아단위조합발휘불동적신경억제성약리작용,여진정최면、항량궐、항초필등.PET가용우활체내수체결합적연구.GABAA-BZ수체PET현상제분위길항제、격동제、반향격동제3류,기중이길항제현상제11C-불마서니최위성숙,재전간、초필증、억욱증、식물상태、성은등신경정신질병중엄범응용.
Gamma-aminobutyric acid type A-benzodiazepine receptors are heterogeneous polypeptide pentamers widely spread in the central nervous system on the neuron membrane.Different subunit combinations educe various neuro-inhibitory pharmacological effects such as sedative,hypnosis,anticonvulsion and anxiolysis.PET can be utilized to study the binding of the receptors in vivo.PET radioligands of gammaaminobutyric acid type A-benzodiazepine receptors can be classified into 3 types:antagonists,agonists and reverse agonists,of which antagonist radiotracer 11C-flumazenil is the most commonly applied in epilepsy,anxiety disorders,depression,vegetative state,addiction and other neuro-psychiatric disorders.