CAJ | 학술논문

目的通过比较早产与足月产孕妇龈沟液及血清中自细胞介素-1β(interleukin-1β,IL-1β)水平,探讨牙周感染与早产之间的关系. 方法以28例先兆早产孕妇和22例足月先兆临产孕妇为研究对象,在临产前采集龈沟液样本,分别随机抽取12份血清样本,采用酶联免疫吸附法(enzyme-linked immunoabsorbent assay,ELISA)检测龈沟液和血清的IL-1β水平. 结果早产组龈沟液IL-1β水平明显高于足月组[(66.66±4.50)pg/ml和(38.77±8.14)pg/ml,P<0.01];早产组血清IL-1β水平与足月组比较无统计学差异[(3.26±0.25)pg/ml和(2.78士0.13)pg/ml,P>0.05)].早产组龈沟液IL-1β水平与出现先兆早产孕周呈负相关(r=-0.555,P<0.05). 结论牙周感染可能和早产相关.
목적 통과비교조산여족월산잉부간구액급혈청중자세포개소-1β(interleukin-1β,IL-1β)수평,탐토아주감염여조산지간적관계. 방법 이28례선조조산잉부화22례족월선조임산잉부위연구대상,재임산전채집간구액양본,분별수궤추취12빈혈청양본,채용매련면역흡부법(enzyme-linked immunoabsorbent assay,ELISA)검측간구액화혈청적IL-1β수평. 결과 조산조간구액IL-1β수평명현고우족월조[(66.66±4.50)pg/ml화(38.77±8.14)pg/ml,P<0.01];조산조혈청IL-1β수평여족월조비교무통계학차이[(3.26±0.25)pg/ml화(2.78사0.13)pg/ml,P>0.05)].조산조간구액IL-1β수평여출현선조조산잉주정부상관(r=-0.555,P<0.05). 결론 아주감염가능화조산상관.
Objective To investigate the association of periodontal diseases in pregnancy with preterm labor by comparing maternal interleukin-1β(IL-1β)levels in gingival cervical fluid(GCF)and serum in preterm labor and full-term pregnancies. Methods Twenty-eight women with preterm labor and 22 women with full-term birth were chosen.GCF samples were collected from all individuals and serum samples were collected from 12 of them,respectively.Interleukin-1β levels were measured by enzyme-linked immunoabsorbent assay(ELISA). Results IL-1β levels in GCF were significantly higher in preterm mothers than those in the full-term group[(66.66 4.50)pg/ml vs(38.77 8.14)pg/ml,P<0.01].And no significant difference was found between the two groups on the serum levels of IL-1β[(3.26 0.25)pg/ml vs(2.78 0.13)pg/ml,P>0.05].Negative correlations were observed between IL-1β levels in GCF and the gcstational age at the onset of preterm labor (r=-0.555,P<0.05). Conclusions Periodontal infections may associated with preterm labor.