CAJ | 학술논문

目的分析青岛某集团职工中甲状腺结节的患病情况及影响因素.方法通过问卷调查、体格检查、甲状腺彩超检查及尿碘检查等方法,收集2010年青岛某集团参与健康查体并且在青岛市居住超过5年的在职及退休职工(9612名)个人健康信息资料及甲状腺结节的检查资料,进行甲状腺结节患病情况调查及其影响因素分析.结果甲状腺结节患病率为36.56％( 3514/9612),单发结节及多发结节的患病率分别为18.39％ (1768/9612)和18.16％ (1746/9612).随着尿碘水平增加,甲状腺多发结节患病率从25.51％ (366/1435)(尿碘≤100 μg/L时)逐渐下降为12.99％ (214/1648)(尿碘＞ 300 μg/L时),呈下降趋势(x2 =67.11,P＜0.01).男性和女性的甲状腺结节患病率分别为31.28％ (2283/7299)和53.22％ (1231/2313) (P ＜0.01).随着年龄的增长,男性甲状腺结节患病率从7.95％ (67/843)(19 ～29岁)逐渐增加到58.81％ (267/454)(＞70岁),女性甲状腺结节患病率从23.74％(33/139)(19 ～29岁)逐渐增加到80.38％(127/158)(＞70岁),男、女甲状腺结节患病率均呈增长趋势(男性:x2 =434.12,P＜0.01；女性:x2 =40.74,P＜0.01).logistic回归分析显示:与男性相比,女性更易患甲状腺结节( OR=2.809,95％ CI:2.444～3.228),校正年龄、性别因素后,吸烟( OR=1.394,95％ CI:1.249～1.556)、高血压病史(OR=1.155,95％CI:1.040～1.282)、糖尿病史(OR=1.228,95％CI:1.039 ～1.452)及超重(OR=1.199,95％CI:1.078～1.333)可能是患甲状腺结节的危险因素.结论青岛某集团职工甲状腺结节患病率较高,为减少甲状腺结节发生,应倡导戒烟及控制体重,有高血压病和(或)糖尿病史的患者应积极控制血压及血糖.
목적 분석청도모집단직공중갑상선결절적환병정황급영향인소.방법 통과문권조사、체격검사、갑상선채초검사급뇨전검사등방법,수집2010년청도모집단삼여건강사체병차재청도시거주초과5년적재직급퇴휴직공(9612명)개인건강신식자료급갑상선결절적검사자료,진행갑상선결절환병정황조사급기영향인소분석.결과 갑상선결절환병솔위36.56％( 3514/9612),단발결절급다발결절적환병솔분별위18.39％ (1768/9612)화18.16％ (1746/9612).수착뇨전수평증가,갑상선다발결절환병솔종25.51％ (366/1435)(뇨전≤100 μg/L시)축점하강위12.99％ (214/1648)(뇨전＞ 300 μg/L시),정하강추세(x2 =67.11,P＜0.01).남성화녀성적갑상선결절환병솔분별위31.28％ (2283/7299)화53.22％ (1231/2313) (P ＜0.01).수착년령적증장,남성갑상선결절환병솔종7.95％ (67/843)(19 ～29세)축점증가도58.81％ (267/454)(＞70세),녀성갑상선결절환병솔종23.74％(33/139)(19 ～29세)축점증가도80.38％(127/158)(＞70세),남、녀갑상선결절환병솔균정증장추세(남성:x2 =434.12,P＜0.01；녀성:x2 =40.74,P＜0.01).logistic회귀분석현시:여남성상비,녀성경역환갑상선결절( OR=2.809,95％ CI:2.444～3.228),교정년령、성별인소후,흡연( OR=1.394,95％ CI:1.249～1.556)、고혈압병사(OR=1.155,95％CI:1.040～1.282)、당뇨병사(OR=1.228,95％CI:1.039 ～1.452)급초중(OR=1.199,95％CI:1.078～1.333)가능시환갑상선결절적위험인소.결론 청도모집단직공갑상선결절환병솔교고,위감소갑상선결절발생,응창도계연급공제체중,유고혈압병화(혹)당뇨병사적환자응적겁공제혈압급혈당.
Objective To investigate the prevalence of thyroid nodules and influencing factors among employees of a company in Qingdao.Methods Through questionnaires,physical examination,thyroid ultrasonography and urinary iodine test,personal health information and examinations of thyroid nodules of 9612 serving and retired employees in a company in 2010 who had lived in Qingdao for more than 5 years were collected to investigate the prevalence of thyroid nodules and its influencing factors.Results The prevalence of thyroid nodules was 36.56％ (3514/9612).The prevalence rates of single nodules and multiple nodules were 18.39％ (1768/9612) and 18.16％ (1746/9612) respectively.With increasing urinary iodine level,the prevalence of multiple thyroid nodules decreased from 25.51％ (366/14350) ( urinary iodine ≤100 μg/L) to 12.99％ (214/1648) (urinary iodine ＞ 300 μg/L) showing a clear downward trend(x2 =67.ll,P＜ 0.01 ).The prevalence rates of thyroid nodules among males and females were 31.28％(2283/7299) and 53.22％ ( 1231/2313 ) ( P ＜ 0.01 ) respectively.With increasing age,the prevalence of thyroid nodules gradually increased from 7.95％ ( 67/843 ) ( 19 - 29 years old ) to 58.81％ ( 267/454 )( ＞70 years old) among males and increased from 23.74％ (33/139) ( 19 - 29 years old) to 80.38％(127/158) ( ＞70 years old) among females.The prevalence of thyroid nodules among males and females showed an increasing trend with age ( male:x2 =434.12,P ＜ 0.01 ; female:x2 =40.74,P ＜ 0.01 ).The results of logistic regression showed that compared with males,females were more susceptible to thyroid nodules( OR =2.809,95％CI:2.444 - 3.228 ).Smoking ( OR =1.394,95％CI:1.249 - 1.556 ),hypertension( OR =1.155,95％ CI∶ 1.040 - 1.282 ),diabetes ( OR =1.228,95％ CI:1.039 - 1.452 ) and overweight( OR =1.199,95％ CI:1.078 - 1.333 ) might be risk factors for thyroid nodules after adjusting for age and gender.Conclusion The prevalence of thyroid nodules was high among the employees.In order to reduce the thyroid nodules,smoking cessation and weight control should be promoted.Blood pressure and glucose level should be actively controlled for patients with hypertension and (or) diabetes.