CAJ | 학술논문

目的观察卡培他滨联合奥沙利铂方案(XELOX)治疗晚期胃癌的近期疗效及毒副反应.方法 28例晚期胃癌患者采用XELOX方案化疗:奥沙利铂(L-OHP) 135 mg/m2、卡培他滨(Xeloda):1000 mg/m2bid,dl～14,21天一周期,两周期后评价疗效.结果 28例均可评价疗效,中位TTP为6.5月,中位MST为11.9月,总有效率为53.6％,临床获益率为71.4％；主要不良反应为手足综合征、外周神经麻木、恶心呕吐及骨髓抑制等,均能耐受.结论卡培他滨联合奥沙利铂方案(XELOX)治疗晚期胃癌疗效确切,毒副反应轻,安全性好,可以作为一般状况较差的晚期及复发转移胃癌患者化疗的选择.
목적 관찰잡배타빈연합오사리박방안(XELOX)치료만기위암적근기료효급독부반응.방법 28례만기위암환자채용XELOX방안화료:오사리박(L-OHP) 135 mg/m2、잡배타빈(Xeloda):1000 mg/m2bid,dl～14,21천일주기,량주기후평개료효.결과 28례균가평개료효,중위TTP위6.5월,중위MST위11.9월,총유효솔위53.6％,림상획익솔위71.4％；주요불량반응위수족종합정、외주신경마목、악심구토급골수억제등,균능내수.결론 잡배타빈연합오사리박방안(XELOX)치료만기위암료효학절,독부반응경,안전성호,가이작위일반상황교차적만기급복발전이위암환자화료적선택.
Objective To observe and evaluate the effects and toxicity of Oxaliplatin combined with Capecitabine(XELOX) in the treatment for the advanced gastric cancer.Methods 28 patients with advanced gastric cancer were treated with Oxaliplatin(135 mg/m2) combined with Capoeitabine (1000mg/m2) divided in two daily doses given from dl to d14.Evaluation was performed at the end of 2 cycles.Results All of these 28 patients were evaluated for response,with a total response rate (RR) of 53.6％.The median progression-free survival was 6.5 months and the median overall survival time was 11.9months.The most common adverse effects were hand-foot syndrome,peripheral nervous anaesthesia,gastrointestinal toxicities and myelosuppression.Conclusion Oxaliplatin combined with Capecitabine is safe and effective for advanced gastric cancer treatment,with tolerable side effects.