CAJ | 학술논문

C型利钠肽(CNP)是长骨生长重要的局部调节因子,与受体NPR-B结合后催化cGMP的合成,激活下游因子调节长骨生长.CNP信号系统的调节机制尚未完全阐明,目前已知CNP信号系统与成纤维细胞生长因子受体3(FGFR-3)信号通路存在交联对话.NPR-B基因突变的杂合子可能是引起特发性矮小的原因之一.CNP可作为线性生长的生物标记,用于生长监测及生长障碍性疾病的诊断和治疗.对CNP信号系统与长骨生长关系的深入研究,有助于为今后骨骼发育障碍疾病的药物治疗开辟新途径.
C형리납태(CNP)시장골생장중요적국부조절인자,여수체NPR-B결합후최화cGMP적합성,격활하유인자조절장골생장.CNP신호계통적조절궤제상미완전천명,목전이지CNP신호계통여성섬유세포생장인자수체3(FGFR-3)신호통로존재교련대화.NPR-B기인돌변적잡합자가능시인기특발성왜소적원인지일.CNP가작위선성생장적생물표기,용우생장감측급생장장애성질병적진단화치료.대CNP신호계통여장골생장관계적심입연구,유조우위금후골격발육장애질병적약물치료개벽신도경.
C-type natriuretic peptide (CNP) is an important local regulator of long bone growth. It catalyzes the synthesis of cGMP after binding to its receptor natriuretic peptide receptor-B (NPR-B) ,and regulates long bone growth by activating downstream factors. Though the mechanism of the regulation of CNP signaling remains unclear, it has been demonstrated that CNP signaling has a "cross-talk" with the fibroblast growth factor receptor 3 pathway in cartilate.Heterozygous NPR-B mutations maybe one of the molecular basis of idiopathic short stature. CNP can be used as a biological marker of linear growth, with great importance in growth monitoring, diagnosis and treatment of growth disorders.The research on the mechanism of CNP signaling system in endochondral ossification will contribute to a new medication for bone development disorders in the future.