CAJ | 학술논문

目的通过系统评价总结持续气道正压通气(CPAP)治疗阻塞性睡眠呼吸暂停综合征对其胰岛素抵抗影响的相关循证医学证据.方法关键词、主题词、引文追溯等途径检索Pubmed、Elsevier-SDOL、Embase、Foreign medical journals service、万方医学期刊库和中国学术期刊全文数据库,电子检索1990-2011年CPAP治疗睡眠呼吸暂停综合征(OSA)对其胰岛素抵抗影响的临床随机对照试验(RCT),逐一评价纳入研究的质量,提取入选文献资料,采用RevMan 4.3软件进行meta分析.结果最终纳入4个RCT,共240例OSA患者,meta分析表明CPAP无显著改善OSA患者胰岛素抵抗作用(WMD=-0.29,95％CI-0.86～0.29,P=0.33),纳入文献表明CPAP干预不显著降低OSA患者空腹血糖、血浆胰岛素和糖化血红蛋白.结论 CPAP治疗并没有改善OSA患者胰岛素抵抗、空腹血糖、血浆胰岛素及糖化血红蛋白水平作用.
목적 통과계통평개총결지속기도정압통기(CPAP)치료조새성수면호흡잠정종합정대기이도소저항영향적상관순증의학증거.방법 관건사、주제사、인문추소등도경검색Pubmed、Elsevier-SDOL、Embase、Foreign medical journals service、만방의학기간고화중국학술기간전문수거고,전자검색1990-2011년CPAP치료수면호흡잠정종합정(OSA)대기이도소저항영향적림상수궤대조시험(RCT),축일평개납입연구적질량,제취입선문헌자료,채용RevMan 4.3연건진행meta분석.결과 최종납입4개RCT,공240례OSA환자,meta분석표명CPAP무현저개선OSA환자이도소저항작용(WMD=-0.29,95％CI-0.86～0.29,P=0.33),납입문헌표명CPAP간예불현저강저OSA환자공복혈당、혈장이도소화당화혈홍단백.결론 CPAP치료병몰유개선OSA환자이도소저항、공복혈당、혈장이도소급당화혈홍단백수평작용.
Objective To systematically review the evidence for the effect of CPAP on glucose control in obstructive sleep apnea patients.Methods Searches of Pubmed,Elsevier.SDOL,Google scholar,Foreign medical journals service and WAN FANG DATA,CNKI.Years between 1990 and Aug.2011.As the research must be RCT study.Results Four articles met the inclusion criteria,for total 240 patients,Meta analysis supports that CPAP therapy changes nothing to insulin resistant (WMD =-0.29,95％ CI:-0.86～0.29,P =0.33).Four in criteria articles point out that CPAP does not reduce the level of fasting glucose,plasma insulin and HbA1c.Conclusions The results suggest CPAP can not improve insulin resistant,fasting glucose,plasma insulin and HbA1c of obstructive sleep apnea patients.