CAJ | 학술논문

目的探讨七叶皂苷对BXSB小鼠肾功能的作用.方法采用狼疮模型BXSB小鼠作为实验对象,随机分成A组(正常对照组)、B组(单用激素组)、C组(激素联合大剂量七叶皂苷组)和D组(激素联合小剂量七叶皂苷组),每组10只,干预1个月后检测各组小鼠蛋白尿(尿蛋白试纸检测)及尿素氮、肌酐(自动生化分析仪检测).结果与其余3组相比,激素联合大剂量七叶皂苷组可以明显减少小鼠蛋白尿水平(P<0.05)及改善肾功能指标(血清尿素氮和肌酐)(P<0.05).结论七叶皂苷可以减少BXSB小鼠蛋白尿水平,并对肾功能有保护作用.
목적 탐토칠협조감대BXSB소서신공능적작용.방법 채용랑창모형BXSB소서작위실험대상,수궤분성A조(정상대조조)、B조(단용격소조)、C조(격소연합대제량칠협조감조)화D조(격소연합소제량칠협조감조),매조10지,간예1개월후검측각조소서단백뇨(뇨단백시지검측)급뇨소담、기항(자동생화분석의검측).결과 여기여3조상비,격소연합대제량칠협조감조가이명현감소소서단백뇨수평(P<0.05)급개선신공능지표(혈청뇨소담화기항)(P<0.05).결론 칠협조감가이감소BXSB소서단백뇨수평,병대신공능유보호작용.
Objective To study the effect of escin on proteinuria and renal function of BXSB mice. Methods BXSB mice were divided randomly into group A (control group), B (steroid treatment group), C(steroid combined with high-dose esein treatment group) and D (streroid combined with low-doze escin group). The proteinufia and renal function were detected by albustix and automatic biochemistry analyzer after a month's treatment. Results Group C reduced the level of proteinuria and parameters of renal function (BUN and Cr) significantly when compared with other three groups (P<0.05). Conclusion Escin can reduce the level of proteinuria and protect renal function of BXSB mice.