CAJ | 학술논문

目的分析他达拉非治疗勃起功能障碍( erectile dysfunction,ED)无效的原因及正确指导用药后的效果. 方法应用他达拉非治疗无效的ED患者80例.年龄22～54岁,平均32岁.病程26个月～4年,平均2.6年.行关于药物使用方法的问卷调查,根据调查结果分析不正确用药的原因,进行用药指导.患者服用他达拉非治疗2周后随访,采用2004年国际ED咨询委员会推荐的治疗评价指标性生活日记(SEP)中问题2(是否能够成功插入阴道)和问题3(是否维持足够勃起以成功完成性生活)作为疗效评价指标. 结果 80例患者有1个或多个不正确服用他达拉非的方式:21.2％的患者不知道性刺激是他达拉非起效所必需的,87.5％的患者尝试次数＜4次,57.5％的患者未服用最大推荐剂量20 mg,84.0％的患者服药时情绪紧张或焦虑.65例接受他达拉非再治疗,再治疗的有效率为46.2％( 30/65). 结论不正确用药是导致他达拉非治疗无效的常见原因,对患者进行性教育和正确的用药指导可提高他达拉非的治疗效果.
목적 분석타체랍비치료발기공능장애( erectile dysfunction,ED)무효적원인급정학지도용약후적효과. 방법 응용타체랍비치료무효적ED환자80례.년령22～54세,평균32세.병정26개월～4년,평균2.6년.행관우약물사용방법적문권조사,근거조사결과분석불정학용약적원인,진행용약지도.환자복용타체랍비치료2주후수방,채용2004년국제ED자순위원회추천적치료평개지표성생활일기(SEP)중문제2(시부능구성공삽입음도)화문제3(시부유지족구발기이성공완성성생활)작위료효평개지표. 결과 80례환자유1개혹다개불정학복용타체랍비적방식:21.2％적환자불지도성자격시타체랍비기효소필수적,87.5％적환자상시차수＜4차,57.5％적환자미복용최대추천제량20 mg,84.0％적환자복약시정서긴장혹초필.65례접수타체랍비재치료,재치료적유효솔위46.2％( 30/65). 결론 불정학용약시도치타체랍비치료무효적상견원인,대환자진행성교육화정학적용약지도가제고타체랍비적치료효과.
Objective To assess the cause of tadalafil failure and the feasibility of successfully rechallenging nonresponding patients. Methods A total of 80 consecutive erectile dysfunction ( ED ) patients who claimed poor response to tadalafil were enrolled into the study.A self-administered tadalafil-use questionnaire composed of eight questions was applied to assess how they had used tadalafil.Subjects were given thorough instruction based on individual answers and four doses of tadalafil 20mg.After a 2-week follow-up,end point efficacy of rechallenge was evaluated using the sexual encounter profile (SEP),which was recommended by international advisory panel in 2004. Results A total of 45 subjects had one or more areas of major suboptimal use of tadalafil:21.2％ did not know that sexual stimulation was necessary for tadalafil to work,87.5％ attempted to use tadalafil less than four times,57.5％ took a maximal dose less than 20 mg,and 84％ felt nervous or anxious.Of the 65 patients undergoing tadalafil rechallenge,30 patients answered “yes” to SEP2 and SEP3.The response rate to rechallenge was 46.2％ ( 30/65 ). Conclusions Inappropriate use of tadalafil was major cause of tadalafil non-pesponse.The efficacy of tadalafil could be improved to a better extent by education of patients.