中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2012年
4期
289-292
,共4页
氰戊菊酯%母亲暴露%神经行为学表现
氰戊菊酯%母親暴露%神經行為學錶現
청무국지%모친폭로%신경행위학표현
Fenvalerate%Maternal exposure%Neurobehavioral maniferestations
目的 研究母体哺乳期染毒氰戊菊酯对子代青春期雌鼠感觉运动行为和生活习性的影响.方法 将12只雌小鼠随机分成对照组、7.5和30.0 mg/kg氰戊菊酯染毒组(每组4只母鼠,每窝10只仔鼠,每组20只雌性仔鼠).于仔鼠出生后第1～21天(PND1～PND21)每天给予染毒组母鼠氰戊菊酯(7.5和30.0 mg/kg)灌胃染毒1次,对照组母鼠给予等容积玉米油.观察出生后第35天(PND 35 d)子代青春期雌鼠感觉运动行为和生活习性的变化.结果 与对照组[周边时间:(203.4±53.0)s和站立次数:(30.9±17.3)次]相比,30.0 mg/kg染毒组子代雌鼠[周边时间:(263.4±54.8)s和站立次数:(47.3±16.2)次]明显增加,差异均有统计学意义(P＜0.05).7.5 mg/kg染毒组子代雌鼠抓绳分值[(56.50±50.79)分]和30.0mg/kg染毒组子代雌鼠抓绳分值[(54.73±53.91)分]明显低于对照组[(114.53±53.87)分],差异均有统计学意义(F=4.141,P＜0.05).不同组别子代雌鼠平衡木分值、挖掘量、囤积量、筑巢分值比较,差异均无统计学意义(P＞0.05).结论 母体哺乳期染毒氰戊菊酯可导致子代青春期雌鼠探索和运动协调能力降低及焦虑行为增加,对生活习性无明显影响.
目的 研究母體哺乳期染毒氰戊菊酯對子代青春期雌鼠感覺運動行為和生活習性的影響.方法 將12隻雌小鼠隨機分成對照組、7.5和30.0 mg/kg氰戊菊酯染毒組(每組4隻母鼠,每窩10隻仔鼠,每組20隻雌性仔鼠).于仔鼠齣生後第1～21天(PND1～PND21)每天給予染毒組母鼠氰戊菊酯(7.5和30.0 mg/kg)灌胃染毒1次,對照組母鼠給予等容積玉米油.觀察齣生後第35天(PND 35 d)子代青春期雌鼠感覺運動行為和生活習性的變化.結果 與對照組[週邊時間:(203.4±53.0)s和站立次數:(30.9±17.3)次]相比,30.0 mg/kg染毒組子代雌鼠[週邊時間:(263.4±54.8)s和站立次數:(47.3±16.2)次]明顯增加,差異均有統計學意義(P＜0.05).7.5 mg/kg染毒組子代雌鼠抓繩分值[(56.50±50.79)分]和30.0mg/kg染毒組子代雌鼠抓繩分值[(54.73±53.91)分]明顯低于對照組[(114.53±53.87)分],差異均有統計學意義(F=4.141,P＜0.05).不同組彆子代雌鼠平衡木分值、挖掘量、囤積量、築巢分值比較,差異均無統計學意義(P＞0.05).結論 母體哺乳期染毒氰戊菊酯可導緻子代青春期雌鼠探索和運動協調能力降低及焦慮行為增加,對生活習性無明顯影響.
목적 연구모체포유기염독청무국지대자대청춘기자서감각운동행위화생활습성적영향.방법 장12지자소서수궤분성대조조、7.5화30.0 mg/kg청무국지염독조(매조4지모서,매와10지자서,매조20지자성자서).우자서출생후제1～21천(PND1～PND21)매천급여염독조모서청무국지(7.5화30.0 mg/kg)관위염독1차,대조조모서급여등용적옥미유.관찰출생후제35천(PND 35 d)자대청춘기자서감각운동행위화생활습성적변화.결과 여대조조[주변시간:(203.4±53.0)s화참립차수:(30.9±17.3)차]상비,30.0 mg/kg염독조자대자서[주변시간:(263.4±54.8)s화참립차수:(47.3±16.2)차]명현증가,차이균유통계학의의(P＜0.05).7.5 mg/kg염독조자대자서조승분치[(56.50±50.79)분]화30.0mg/kg염독조자대자서조승분치[(54.73±53.91)분]명현저우대조조[(114.53±53.87)분],차이균유통계학의의(F=4.141,P＜0.05).불동조별자대자서평형목분치、알굴량、돈적량、축소분치비교,차이균무통계학의의(P＞0.05).결론 모체포유기염독청무국지가도치자대청춘기자서탐색화운동협조능력강저급초필행위증가,대생활습성무명현영향.
Objective To explore the effects of rat maternal exposure to fenvalerate during lactation on behaviors development in rat pubertal female offspring.Methods Twelve ICR matemal mice were randomly divided into 7.5 and 30.0 mg/kg fenvalerate exposure groups and control group (four dams each group,ten pups each darn,half male half female,twenty female pups each group).The exposure groups were orally exposed to fenvalerate at the doses of 7.5 and 30 mg/kg a day from postnatal day 1 (PND 1) to PND21.The control group was exposed to corn oil.The effects of maternal fenvalerate exposure during lactation on motor and species-typical behaviors in female offspring were observed on the PND 35.Results The peripheral time and standing frequency of 30.0 mg/kg exposure group were (263.4±54.8) s and (47.3±16.2) times,which were significantly higher than those [(203.4±53.0) s and (30.9±17.3) times] of control group (P＜0.05).The scores in 7.5 mg/kg and 30.0 mg/kg exposure groups were 56.50 ±50.79 and 54.73 ±53.91,respectively,which were significantly lower than that (114.53±53.87) in control group (P＜0.05).However,no significant differences in beam walking scores,food hoarding quantity,food digging quantity,and nest construction scores between two exposure groups were found (P＞0.05).Conclusion The rat maternal exposure to fenvalerate during lactation could decrease the ability of exploration and motor condition and increase the anxiety but not affect life habit in rat pubertal female offspring.
