中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2009年
11期
901-904
,共4页
磷脂酶A2%冠状动脉疾病%C反应蛋白质
燐脂酶A2%冠狀動脈疾病%C反應蛋白質
린지매A2%관상동맥질병%C반응단백질
Phospholipases A2%Coronary disease%C-reactive protein
目的 观察老年人脂蛋白相关磷脂酶A2(Lp-PLA2)水平与冠心病冠状动脉造影病变程度及冠心病危险因素的关系. 方法 测定90例临床怀疑冠心病行冠状动脉造影老年患者Lp-PLA2、超敏C反应蛋白(hs-CRP),血脂等指标,根据冠状动脉造影结果以病变支数及Gensini积分评价冠状动脉病变程度,分析Lp-PLA2与冠心病的关系. 结果冠心病组Lp-PLA2水平较对照组明显升高[(352.7±129.0)μg/L与(204.0±59.7)μg/L,P<0.01].Lp-PLA2水平随着冠状动脉病变支数和Gensini积分的增加而升高.Lp-PLA2与年龄(r=0.25,P<0.05)、三酰甘油(r=0.33,P<0.01)、低密度脂蛋白胆固醇(r=0.27,P<0.05)、载脂蛋白B(r=0.36,P<0.01)呈正相关.在冠心病组,Lp-PLA2与年龄呈正相关(r=0.29,P<0.05).Stepwise回归分析结果显示Lp-PLA2与冠心病相关. 结论 冠心病患者Lp-PLA2水平升高,其水平的高低可能反映冠状动脉病变的严重程度.为冠心病的危险因素之一.
目的 觀察老年人脂蛋白相關燐脂酶A2(Lp-PLA2)水平與冠心病冠狀動脈造影病變程度及冠心病危險因素的關繫. 方法 測定90例臨床懷疑冠心病行冠狀動脈造影老年患者Lp-PLA2、超敏C反應蛋白(hs-CRP),血脂等指標,根據冠狀動脈造影結果以病變支數及Gensini積分評價冠狀動脈病變程度,分析Lp-PLA2與冠心病的關繫. 結果冠心病組Lp-PLA2水平較對照組明顯升高[(352.7±129.0)μg/L與(204.0±59.7)μg/L,P<0.01].Lp-PLA2水平隨著冠狀動脈病變支數和Gensini積分的增加而升高.Lp-PLA2與年齡(r=0.25,P<0.05)、三酰甘油(r=0.33,P<0.01)、低密度脂蛋白膽固醇(r=0.27,P<0.05)、載脂蛋白B(r=0.36,P<0.01)呈正相關.在冠心病組,Lp-PLA2與年齡呈正相關(r=0.29,P<0.05).Stepwise迴歸分析結果顯示Lp-PLA2與冠心病相關. 結論 冠心病患者Lp-PLA2水平升高,其水平的高低可能反映冠狀動脈病變的嚴重程度.為冠心病的危險因素之一.
목적 관찰노년인지단백상관린지매A2(Lp-PLA2)수평여관심병관상동맥조영병변정도급관심병위험인소적관계. 방법 측정90례림상부의관심병행관상동맥조영노년환자Lp-PLA2、초민C반응단백(hs-CRP),혈지등지표,근거관상동맥조영결과이병변지수급Gensini적분평개관상동맥병변정도,분석Lp-PLA2여관심병적관계. 결과관심병조Lp-PLA2수평교대조조명현승고[(352.7±129.0)μg/L여(204.0±59.7)μg/L,P<0.01].Lp-PLA2수평수착관상동맥병변지수화Gensini적분적증가이승고.Lp-PLA2여년령(r=0.25,P<0.05)、삼선감유(r=0.33,P<0.01)、저밀도지단백담고순(r=0.27,P<0.05)、재지단백B(r=0.36,P<0.01)정정상관.재관심병조,Lp-PLA2여년령정정상관(r=0.29,P<0.05).Stepwise회귀분석결과현시Lp-PLA2여관심병상관. 결론 관심병환자Lp-PLA2수평승고,기수평적고저가능반영관상동맥병변적엄중정도.위관심병적위험인소지일.
Objective To observe the correlation between lipoprotein-associated phospholipase A2(Lp-PLA2) levels and coronary artery disease (CAD), extent of angiographic coronary artery lesions and risk factors of CAD in the elderly. Methods Plasma levels of Lp-PLA2, triglyceride (TG), total cholesterol(TC), low density lipoprotein(LDL-C), high density lipoprotein cholesterol (HDL-C) and high sensitivity C-reactive protein(hs-CRP) were measured in 67 elderly patients with angiographic CAD meanwhile in 23 normal controls without angiographic coronary artery lesions. The extent of coronary artery lesions was evaluated according to the number of vessel lesions (divided into single, double and triple-vessel lesions) and Gensini scoring system. Then the relationship between Lp-PLA2 and CAD was assessed. Results The plasma levels of Lp-PLA2 were significantly higher in the CAD group than in the controls [(352.7 ± 129.0) vs. (204.0 ± 59. 7) μg/L, P < 0. 01]. Lp-PLA2 levels increased with the number of coronary artery lesions and Gensini score, then were positively correlated with age(r= 0. 25, P<0. 05) ,TC(r=0. 33, P<0. 01) ,LDL-C(r=0.27, P< 0. 05),apoB(r=0. 36, P<0. 01). The levels of LP-PLA2 and LP(a) were associated with CAD by using stepwise regression analysis. Conclusions In the eldly, the levels of LP-PLA2 are much higher in angiographic CAD, and these may reflect the severity of CAD. LP-PLA2 is a risk factor for CAD.
