CAJ | 학술논문

巨噬细胞作为重要的固有免疫细胞和抗原提呈细胞,在机体抗感染免疫中发挥着重要作用.在不同的微环境下,巨噬细胞可发生表型和功能极化从而呈现出不同的功能,一般将经典途径和替代途径活化的巨噬细胞(M1型和M2型)作为巨噬细胞功能可塑性调变的两个极端.随着研究的深入,巨噬细胞极化类型的诱导及特点也逐渐被揭示,其在微生物感染免疫中的作用日益受到重视.
거서세포작위중요적고유면역세포화항원제정세포,재궤체항감염면역중발휘착중요작용.재불동적미배경하,거서세포가발생표형화공능겁화종이정현출불동적공능,일반장경전도경화체대도경활화적거서세포(M1형화M2형)작위거서세포공능가소성조변적량개겁단.수착연구적심입,거서세포겁화류형적유도급특점야축점피게시,기재미생물감염면역중적작용일익수도중시.
Macrophages are a group of important innate immune cells and antigen presenting cells,which play important roles in anti-infection immunity.Under different microenvironments,macrophages can be polarized to assume different phenotypes and show different functions.Classical pathway activated macrophages ( M1 ) and alternative pathway-activated macrophages (M2) are considered as the extremes of this polarization.Recently,the induction and characteristic of M1/M2 has been gradually revealed.The role of macrophage polarization in microbial infection immunity has received increasing attention.