CAJ | 학술논문

目的观察慢性阻塞性肺疾病(COPD)患者血清白细胞介素-18(IL-18)、单核细胞趋化蛋白-1( MCP-1)的表达,探讨其临床意义.方法采用病例对照研究的方法,测定COPD急性加重期(急性期组30例)、稳定期患者(稳定期组30例)及健康对照者(对照组30例)血清IL-18、MCP-1浓度,并同时测定各组血清C反应蛋白(CRP)浓度及肺功能指标[1秒钟用力肺活量(FEV1),用力呼气1秒率( FEV1)/用力肺活量(FVC)％],进行比较及相关性分析.结果 COPD急性加重期患者血清IL-18、MCP-1浓度高于稳定期[IL-18分别为(69.29±16.14)、( 53.15±14.74) ng/L,MCP-1分别为(123.95±32.06)、(96.46±18.24) ng/L],且均高于正常对照组[IL-18( 37.53±14.55) ng/L,MCP-1( 60.86±17.26) ng/L],差异均有统计学意义(F值分别为10.975,18.101,P均＜0.01)；急性加重期血清IL-18、MCP-1、CRP之间呈正相关(r=0.688,P＜0.05；r =0.663,P＜0.05；r =0.825,P＜0.01),与FEV1、FCV1/FVC％呈负相关(r=-0.732,P＜0.01；r=-0.586,P＜0.05)；稳定期血MCP-1与IL-18呈正相关(r=0.674,P＜0.05),与CRP亦呈正相关(r=0.719,P＜0.05),与FEV1、FCV1/FVC％呈负相关(r=-0.512,P＜0.05；r=-0.557,P＜0.05).结论血清IL-18、MCP-1可作为COPD患者的炎症性标志物之一,与气道炎症和气流受限有关.
목적 관찰만성조새성폐질병(COPD)환자혈청백세포개소-18(IL-18)、단핵세포추화단백-1( MCP-1)적표체,탐토기림상의의.방법 채용병례대조연구적방법,측정COPD급성가중기(급성기조30례)、은정기환자(은정기조30례)급건강대조자(대조조30례)혈청IL-18、MCP-1농도,병동시측정각조혈청C반응단백(CRP)농도급폐공능지표[1초종용력폐활량(FEV1),용력호기1초솔( FEV1)/용력폐활량(FVC)％],진행비교급상관성분석.결과 COPD급성가중기환자혈청IL-18、MCP-1농도고우은정기[IL-18분별위(69.29±16.14)、( 53.15±14.74) ng/L,MCP-1분별위(123.95±32.06)、(96.46±18.24) ng/L],차균고우정상대조조[IL-18( 37.53±14.55) ng/L,MCP-1( 60.86±17.26) ng/L],차이균유통계학의의(F치분별위10.975,18.101,P균＜0.01)；급성가중기혈청IL-18、MCP-1、CRP지간정정상관(r=0.688,P＜0.05；r =0.663,P＜0.05；r =0.825,P＜0.01),여FEV1、FCV1/FVC％정부상관(r=-0.732,P＜0.01；r=-0.586,P＜0.05)；은정기혈MCP-1여IL-18정정상관(r=0.674,P＜0.05),여CRP역정정상관(r=0.719,P＜0.05),여FEV1、FCV1/FVC％정부상관(r=-0.512,P＜0.05；r=-0.557,P＜0.05).결론 혈청IL-18、MCP-1가작위COPD환자적염증성표지물지일,여기도염증화기류수한유관.
Objective To investigate the expression level and clinical significance of serum IL-18 and MCP-1 in patients with Chronic Obstructive Pulmonary Disease(COPD).Methods Serum IL-18 and MCP-1 levels were measured in healthy people( control group,30 cases) and in patients with COPD (acute stage group and stable stage group,30 cases in each group).At the same time,the level of serum CRP and forced expiratory volume in one second ( FEV1 ),the forced expiratory volume in one second/forced vital capacity ( FEV1/FVC％ ) were tested in the three groups.The variation.of the level of serum IL-18 and MCP-1 and the correlation between these index with lung function and CRP were analyzed.Results The levels of serum IL-18 and MCP-1 in acute stage group ( IL-18 [ 69.29 ± 16.14 ] ng/L,MCP-1 [ 123.95 ± 32.06 ] ng/L) were significantly higher than those in stable stage group ( IL-18 [ 53.15 ± 14.74 ] ng/L,MCP-1 [ 96.46 ± 18.24 ] ng/L) ( F =10.975,P ＜0.01 ),and also significantly higher than those in control group ( IL-18 [ 37.53 ± 14.55 ] ng/L,MCP-1 [60.86 ± 17.26] ng/L) ( F =18.101,P ＜ 0.01 ).In acute stage group,positive correlations were obtained among the level of serum IL-18,MCP-1 and CRP ( r =0.688,P ＜ 0.05 ; r =0.663,P ＜ 0.05 ; r =0.825,P ＜0.01 ),and they were correlated negatively with FEV1 and FEV1/FVC％ ( r =- 0.732,P ＜ 0.01 ;r =- 0.586,P ＜0.05 ).In stable stage group,the level of serum MCP-1 was correlated positively with the level of IL-18( r =0.674,P ＜ 0.05 ) and with the level of CRP ( r =0.719,P ＜ 0.05 ),but it was correlated negatively with FEV1 and FEV1/FVC％ ( r =-0.512,P ＜ 0.05 ;r =-0.557,P ＜ 0.05 ).Conclusion The serum IL-18 and MCP-1may be one of the inflammation markers in patients with COPD and may be associated with airway inflammation and limited airflow.