CAJ | 학술논문

目的探讨非酒精性脂肪性肝病(NAFLD)患者血清瘦素、脂联素的变化及其与胰岛素抵抗的关系. 方法选取NAFLD患者60例,同期门诊体检健康者60名为对照组,ELJSA法测定血清瘦素、脂联素水平,并检测体质量指数、腰臀比、甘油三酯、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、空腹血糖、ALT、AST、γ-谷氨酰转肽酶(GGT),稳态模型评估的胰岛素抵抗指数(HOMA-IR).采用SPSS10.0软件包进行统计学分析,计量资料差异性比较用方差分析和t检验,多因素相关性用Spearman分析和Logistic回归分析. 结果血清瘦素、脂联素水平NAFLD组分别为(12.37±1.99)μg/L和(12.69±2.83)mg/L,对照组分别为(5.20±1.03)μg/L和(22.83±4.61)mg/L,t值分别为24.661和14.516,P值均<0.01;HOMA-IR,NAFLD组为4.86±0.63,对照组为1.91±0.41,t值为30.451,P<0.01.Logistic多因素回归分析显示瘦素与腰臀围之比、HOMA-IR、空腹血糖呈独立正相关,β值分别为8.175、0.974和0.564,P值均<0.01;脂联素与HOMA-IR、体质量指数呈独立负相关,β值分别为-0.495和-0.314,P值均<0.01.结论 NAFLD患者血清瘦素、脂联素的变化与胰岛素抵抗有关.
목적 탐토비주정성지방성간병(NAFLD)환자혈청수소、지련소적변화급기여이도소저항적관계. 방법 선취NAFLD환자60례,동기문진체검건강자60명위대조조,ELJSA법측정혈청수소、지련소수평,병검측체질량지수、요둔비、감유삼지、총담고순、고밀도지단백담고순(HDL-C)、공복혈당、ALT、AST、γ-곡안선전태매(GGT),은태모형평고적이도소저항지수(HOMA-IR).채용SPSS10.0연건포진행통계학분석,계량자료차이성비교용방차분석화t검험,다인소상관성용Spearman분석화Logistic회귀분석. 결과 혈청수소、지련소수평NAFLD조분별위(12.37±1.99)μg/L화(12.69±2.83)mg/L,대조조분별위(5.20±1.03)μg/L화(22.83±4.61)mg/L,t치분별위24.661화14.516,P치균<0.01;HOMA-IR,NAFLD조위4.86±0.63,대조조위1.91±0.41,t치위30.451,P<0.01.Logistic다인소회귀분석현시수소여요둔위지비、HOMA-IR、공복혈당정독립정상관,β치분별위8.175、0.974화0.564,P치균<0.01;지련소여HOMA-IR、체질량지수정독립부상관,β치분별위-0.495화-0.314,P치균<0.01.결론 NAFLD환자혈청수소、지련소적변화여이도소저항유관.
Objective To investigate the serum leptin and adiponectin levels in nonalcoholic fatty liver disease (NAFLD) patients, and their relationship with insulin resistance. Methods A total of 120 cases were enrolled and divided into two groups: NAFLD group (n = 60) and normal control group (n = 60). The serum levels of leptin and adiponectin were measured by EL1SA. The body mass index (BMI), waist-to-hip ratio (WHR), triglyceride (TG), total cholesterol (Tchol), high-density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), fasting blood glucose (FBG) and HOMA-IR (homeostasis model assessment insulin resistance) were detected and analyzed. Results Compared with control group, the serum leptin level in NAFLD group was Significantly higher [(12.37 ± 1.99) μg/Lvs (5.20 ± 1.03)μg/L,P<0.01], while the serum adiponectin level was significantly lower [(12.69 ± 2.83) mg/L vs (22.83 ± 4.61) mg/L, P < 0.01]. HOMA-IR was also much higher in NAFLD group than that in control group[(4.86 ± 0.63) vs (1.91 ± 0.41), P < 0.01]. Logistic regression analysis showed that leptin was positively correlated with WHR ( P = 8.175, P < 0.01), HOMA-IR ( P = 0.974, P < 0.01 ), FBG ( β = 0.564, P < 0.01). In contrast, adiponectin inversely associated with HOMA-IR ( β = -0.495, P < 0.01 ) and BMI ( β = -0.314, P < 0.01) respectively. Conclusions The increased serum leptin level and decreased serum adiponectin level in NAFLD patients independently associated with HOMA-IR.