CAJ | 학술논문

随着多种生物基因组测序计划的完成,应用蛋白质组学方法在整体水平上研究复杂生命现象的后基因组时代已经到来.蛋白质是生物生长、分化、代谢及调控的主要执行者,因而蛋白质组学方法成为研究生物体不同状态下差异蛋白表达非常重要的技术手段.差异蛋白质组学主要用于筛选和鉴定不同种类和状态下各样本之间蛋白质组之间的区别和变化,寻找任何有意义的因素所引起的样本间的差异蛋白质谱,从而进一步认识个体生理的发展与变化.一些寄生虫的蛋白质组作为蛋白质组学研究的一个分支也迅速发展起来.该文着重对差异蛋白质组学在寄生虫中的研究作一综述.
수착다충생물기인조측서계화적완성,응용단백질조학방법재정체수평상연구복잡생명현상적후기인조시대이경도래.단백질시생물생장、분화、대사급조공적주요집행자,인이단백질조학방법성위연구생물체불동상태하차이단백표체비상중요적기술수단.차이단백질조학주요용우사선화감정불동충류화상태하각양본지간단백질조지간적구별화변화,심조임하유의의적인소소인기적양본간적차이단백질보,종이진일보인식개체생리적발전여변화.일사기생충적단백질조작위단백질조학연구적일개분지야신속발전기래.해문착중대차이단백질조학재기생충중적연구작일종술.
With the completion of many genome sequencing projects of organisms, the post-genomic era has arrived with the application of proteomics in the overall level of complexity of life. Protein is the executor of biological growth, differentiation, metabolism and regulation, and thus it becomes a very important technical method in examination of the differential protein expression of organism under different conditions. Differential proteomics is mainly used for selection and identification of the differences and changes between the proteins at the different types and state of samples, looking for any significant factors that cause the difference in protein spectrum of the sample, thus to understand the development and change of individual physiology. The proteome of some parasites has developed rapidly as a branch of proteomics. In this paper, we reviewed the differential proteomics applied in parasite research.