国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
INTERNATIONAL JOURNAL OF BIOLOGICALS
2011年
5期
262-266
,共5页
肠毒素类%免疫,黏膜%佐剂,免疫
腸毒素類%免疫,黏膜%佐劑,免疫
장독소류%면역,점막%좌제,면역
Enterotoxins%Immunity,mucosal%Adjuvants,immunologic
不耐热肠毒素B亚单位(heat-labile enterotoxin B subunit,LTB)是产肠毒素性大肠杆菌分泌到细胞周质的肠毒素的组成部分,具有黏膜免疫佐剂活性,可介导细菌与肠上皮细胞结合.此文对LTB的结构、重组表达、作为黏膜佐剂的免疫学评价和作用机制等方面进行综述.
不耐熱腸毒素B亞單位(heat-labile enterotoxin B subunit,LTB)是產腸毒素性大腸桿菌分泌到細胞週質的腸毒素的組成部分,具有黏膜免疫佐劑活性,可介導細菌與腸上皮細胞結閤.此文對LTB的結構、重組錶達、作為黏膜佐劑的免疫學評價和作用機製等方麵進行綜述.
불내열장독소B아단위(heat-labile enterotoxin B subunit,LTB)시산장독소성대장간균분비도세포주질적장독소적조성부분,구유점막면역좌제활성,가개도세균여장상피세포결합.차문대LTB적결구、중조표체、작위점막좌제적면역학평개화작용궤제등방면진행종술.
Heat-labile enterotoxin B subunit (LTB) is a part of enterotoxin secreted into cellular periplasm by enterotoxigenic Escherichia coli (ETEC).LTB has mucosal immunoadjuvant activity,and can mediate ETEC binding to intestinal epithelium cells.This paper summarizes structure,recombination expression,immunity evaluation as mucosal adjuvant and effect mechanism of LTB.
